Evidence map›Paper›PMID 35368849›Full record

ArticleComputational toxicology (Amsterdam, Netherlands)2022

Evaluating Confidence in Toxicity Assessments Based on Experimental Data and

Candice Johnson, Lennart T Anger, Romualdo Benigni, David Bower, Frank Bringezu, Kevin M Crofton, Mark T D Cronin, Kevin P Cross, Magdalena Dettwiler, Markus Frericks and 9 more

Abstract read
In one paragraph

Article in Computational toxicology (Amsterdam, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. The TOXIN knowledge graph: supporting animal-free risk assessment of cosmetics.Database : the journal of biological databases and curation · 2025
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Frontiers in toxicology · 2023
    Article
  9. Principles and Procedures for Assessment of Acute Toxicity IncorporatingComputational toxicology (Amsterdam, Netherlands) · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Candice JohnsonInstem, 1393 Dublin Rd, Columbus, OH 43215, USA.
Lennart T AngerGenentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Romualdo BenigniAlpha-PreTox, via G.Pascoli 1, 00184 Roma, Italy.
David BowerInstem, 1393 Dublin Rd, Columbus, OH 43215, USA.
Frank BringezuMerck Healthcare KGaA, Frankfurter Str. 250, U009/101.
Kevin M CroftonR3Fellows LLC, Durham, NC.
Mark T D CroninSchool of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, L3 3AF, UK.
Kevin P CrossInstem, 1393 Dublin Rd, Columbus, OH 43215, USA.
Magdalena DettwilerIdorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, 4123 Allschwill, Switzerland.
Markus FrericksBASF SE, APD/ET, Li 444, Speyerer St 2, 67117 Limburgerhof, Germany.
Fjodor MelnikovGenentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.
Scott MillerInstem, 1393 Dublin Rd, Columbus, OH 43215, USA.
David W RobertsSchool of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, L3 3AF, UK.
Diana Suarez-RodriguezFStox consulting LTD, 2 Brooks Road Raunds Wellingborough NN9 6NS.
Alessandra RoncaglioniLaboratory of Environmental Chemistry and Toxicology, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Elena Lo PiparoChemical Food Safety Group, Nestlé Research, Lausanne, Switzerland.
Raymond R TiceRTice Consulting, Hillsborough, NC 27278, USA.
Craig ZwicklTransendix LLC, 1407 Moores Manor, Indianapolis, IN 46229, USA.
Glenn J MyattInstem, 1393 Dublin Rd, Columbus, OH 43215, USA.

Funding

Rapid response toxicology prediction platformR44ES026909 · NIEHS · LEADSCOPE, INC. · PI MYATT, GLENN JOHN · 2018 to 2019
$1000k
NIEHS NIH HHS R44 ES026909
6 · The paper itself

Abstract

Understanding the reliability and relevance of a toxicological assessment is important for gauging the overall confidence and communicating the degree of uncertainty related to it. The process involved in assessing reliability and relevance is well defined for experimental data. Similar criteria need to be established for

Identifiers

PMID35368849
PMCPMC8967148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.