Evidence map›Paper›PMID 35368774›Full record

ArticleNature aging2022

DNA methylation clocks tick in naked mole rats but queens age more slowly than nonbreeders.

Steve Horvath, Amin Haghani, Nicholas Macoretta, Julia Ablaeva, Joseph A Zoller, Caesar Z Li, Joshua Zhang, Masaki Takasugi, Yang Zhao, Elena Rydkina and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Nature aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 107 citations in OpenAlex.

  1. Evolutionary genetics of ageing.Nature reviews. Genetics · 2026
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  16. Workload distribution in wild Damaraland mole-rat groups.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  17. The androgen clock is an epigenetic predictor of long-term male hormone exposure.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Steve HorvathDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-4110-3589
Amin HaghaniDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Nicholas MacorettaDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.
Julia AblaevaDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.
Joseph A ZollerDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-6309-0291
Caesar Z LiDepartment of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-3907-7983
Joshua ZhangDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-4488-1175
Masaki TakasugiDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.ORCID 0000-0001-9880-1225
Yang ZhaoDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.ORCID 0000-0002-8703-3678
Elena RydkinaDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.
Zhihui ZhangDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.
Stephan EmmrichDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.ORCID 0000-0002-0537-4242
Ken RajRadiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, UK.ORCID 0000-0002-3744-265X
Andrei SeluanovDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.ORCID 0000-0003-3400-538X
Chris G FaulkesSchool of Biological and Chemical Sciences, Queen Mary University of London, London, UK.ORCID 0000-0002-5228-9075
Vera GorbunovaDepartments of Biology and Medicine, University of Rochester, Rochester, NY, USA.ORCID 0000-0001-8979-0333
University of Rochester · USUniversity of California, Los Angeles · USSivas State Hospital · TRPublic Health England · GBQueen Mary University of London · GB

Funding

The role of hyaluronan in longevity and cancer resistance of longest-lived rodentP01AG047200 · NIA · UNIVERSITY OF ROCHESTER · PI Andrei Seluanov · 2014 to 2026
$36.9M
The role of SIRT6 posttranslational modifications in aging and genome stability. Supplement: Testing SIRT6 activators as potential Alzheimer's disease therapy.R01AG027237 · NIA · UNIVERSITY OF ROCHESTER · PI Vera Gorbunova · 2006 to 2026
$6.2M
Regulation of epigenome stability by SIRT6 during aging. Supplement: Does centenarian variant of SIRT6 or bowhead whale SIRT6 confer protection from Alzheimer's disease?R37AG046320 · NIA · UNIVERSITY OF ROCHESTER · PI Andrei Seluanov · 2019 to 2026
$4.7M
Validation and optimization of epigenetic clocksU01AG060908 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2018 to 2022
$3.4M
Integrative Omics to enhance therapeutics development for healthy agingUH3AG064706 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI MILLER, RICHARD A, SCHORK, NICHOLAS JOSEPH · 2021 to 2024
$3.3M
NIA NIH HHS P01 AG047200NIA NIH HHS R01 AG027237NIA NIH HHS R37 AG046320NIA NIH HHS U01 AG060908NIA NIH HHS UH3 AG064706
6 · The paper itself

Abstract

Naked mole rats (NMRs) live an exceptionally long life, appear not to exhibit age-related decline in physiological capacity and are resistant to age-related diseases. However, it has been unknown whether NMRs also evade aging according to a primary hallmark of aging: epigenetic changes. To address this question, we profiled

Indexed as

DNA MethylationTicksAgingAnimalsEpigenesis, GeneticHumansMole Rats

Identifiers

PMID35368774
PMCPMC8975251
OpenAlexW4200336106

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.