ReviewEXCLI journal2022
Molecular mechanisms linking stress and insulin resistance.
Review in EXCLI journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Relationship between Psychological Stress and Anthropometric, Biological Outcomes: A Systematic Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Threat-induced neural prioritization: a life history framework for energy allocation under chronic predator stress.Oecologia · 2026Review
- Association Between Psychological Distress and Glycaemic Control Among Adults with Diabetes Mellitus in Saudi Arabia.Healthcare (Basel, Switzerland) · 2026Article
- Technostress and Insulin Resistance Risk: A Cross-Sectional Analysis of 104,175 Spanish Workers Using TyG, TyG-BMI, METS-IR, and SPISE Indices.Medical sciences (Basel, Switzerland) · 2026Article
- Review
- Determinants of the plasma metabolome: cross-sectional and longitudinal associations over six years in the NESDA cohort.EBioMedicine · 2026Article
- Genomic structural equation modeling elucidates the genetic mechanisms underlying allostatic load.Comprehensive psychoneuroendocrinology · 2026Article
- Comparative Analysis of the Association of Biomarkers of Endothelial Dysfunction and Systemic Inflammation in Patients with Coronary Artery Disease with the Presence/Absence of Personality Type D.Journal of clinical medicine · 2026Article
- IntegrativeNutrients · 2026Article
- Health Disparities Between Stress-Related Mental Health Conditions and Chronic Physical Health Conditions Among Hispanic and Latinx Sexual and Gender Minority Individuals: Findings from the All of Us Research Program.Psychology of sexual orientation and gender diversity · 2026Article
- The Neuro-Cardio-Renal Stress Index (NCR-SI): A Pragmatic Composite Framework for Characterizing Multisystem Burden in Multimorbid Patients.Diagnostics (Basel, Switzerland) · 2026Article
- An exploratory study of glycemic biomarkers and rTMS treatment outcomes in treatment-resistant depression.BMC psychiatry · 2026Article
- Associations Between Noise-Induced Hearing Loss and the Risk of High Fasting Blood Glucose Among the Air Force Population.Safety and health at work · 2026Article
- Hypothesis: Nutrient Off-Loading and Ectopic Fat Reduction Reverse Insulin Resistance and Improve Cardiovascular Outcomes in Type 2 Diabetes-A Narrative Review.International journal of molecular sciences · 2026Review
- Effect of stress on insulin resistance among shift workers based on findings from the Korea National Health and Nutrition Examination Survey (2019, 2021): a retrospective cross-sectional study.Journal of Korean biological nursing science · 2026Article
- Insulin Resistance and Inflammation.International journal of molecular sciences · 2026Review
- The interplay between thrombosis, stress, and social risk factors in trans persons on gender affirming hormone therapy.Research and practice in thrombosis and haemostasis · 2026Article
- Nutritional-metabolic risk stratification for delirium in surgical critically ill patients: joint associations of the triglyceride-glucose index and stress hyperglycemia ratio.Frontiers in nutrition · 2026Article
- Effect of a Combined Antidepressant Drug Flupentixol-Melitracen on Glucose Level and Expression of Insulin-Like Peptide Genes DILP5 and DILP6 in Drosophila melanogaster.BioMed research international · 2026Article
- Effects of a health literacy program on self-management behaviors of patients with uncontrolled type 2 diabetes in Thailand: A quasi-experimental study.Belitung nursing journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date, there is ample evidence to support the strong relationship between stress and insulin resistance. While diabetes mellitus acts as a potent stress inducer, stress may be an upstream event for insulin resistance as well. It is widely recognized that diabetes mellitus is more prevalent among people who have a stressful lifestyle; however, the underlying mechanisms are not well understood. In the current study, we surveyed the scientific literature for possible interactions between stress and insulin resistance and found that stress can impair glucose homeostasis, working through at least six molecular pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.