Evidence map›Paper›PMID 35368333›Full record

ArticlePeerJ2022

Rapid parameter estimation for selective inversion recovery myelin imaging using an open-source Julia toolkit.

Nicholas J Sisco, Ping Wang, Ashley M Stokes, Richard D Dortch

Open access · goldAbstract read
In one paragraph

Article in PeerJ, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nicholas J SiscoDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States.ORCID 0000-0003-2091-868X
Ping WangDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States.ORCID 0000-0003-0490-005X
Ashley M StokesDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States.ORCID 0000-0003-1137-5003
Richard D DortchDepartment of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States.
Barrow Neurological Institute · US

Funding

Quantitative Assessment of Peripheral Nerve Injury and Repair via Multi-Parametric MRIR01NS097821 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DORTCH, RICHARD · 2016 to 2020
$1.7M
MRI Biomarkers of Disease Progression in Inherited NeuropathiesR21TR003312 · NCATS · WAYNE STATE UNIVERSITY · PI DORTCH, RICHARD, LI, JUN · 2021 to 2022
$440k
NCATS NIH HHS R21 TR003312NINDS NIH HHS R01 NS097821
6 · The paper itself

Abstract

Background: Magnetic resonance imaging (MRI) is used extensively to quantify myelin content, however computational bottlenecks remain challenging for advanced imaging techniques in clinical settings. We present a fast, open-source toolkit for processing quantitative magnetization transfer derived from selective inversion recovery (SIR) acquisitions that allows parameter map estimation, including the myelin-sensitive macromolecular pool size ratio ( Methods: To test the accuracy of this toolkit, we simulated SIR images with varying Results: Estimated SIR parameter maps from our Julia toolkit agreed with simulated values (LCCC > 0.98). This toolkit was further validated using BSA phantoms and a whole brain scan at 3T. In both cases, SIR parameter estimates were consistent with published values using MATLAB. However, compared to earlier work using MATLAB, our Julia toolkit provided an approximate 20-fold reduction in computational time. Conclusions: Presented here, we developed a fast, open-source, toolkit for rapid and accurate SIR MRI using Julia. The reduction in computational cost should allow SIR parameters to be accessible in clinical settings.

Indexed as

Magnetic Resonance ImagingMyelin SheathBrainComputer SimulationHumansNeuroimagingJulia LanguageMRIMultiple SclerosisQuantitative MRI

Identifiers

PMID35368333
PMCPMC8973461
OpenAlexW4226025394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.