Evidence map›Paper›PMID 35368305›Full record

ArticleFrontiers in behavioral neuroscience2022

Age-Dependent Neuropsychiatric Symptoms in the NF-κB/c-Rel Knockout Mouse Model of Parkinson's Disease.

Edoardo Parrella, Federico Del Gallo, Vanessa Porrini, Cristina Gussago, Marina Benarese, Paolo Francesco Fabene, Marina Pizzi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Edoardo ParrellaDivision of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Federico Del GalloSection of Anatomy and Histology, Department of Neurosciences, Biomedicine and Movement Sciences, School of Medicine, University of Verona, Verona, Italy.
Vanessa PorriniDivision of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Cristina GussagoDivision of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Marina BenareseDivision of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Paolo Francesco FabeneSection of Anatomy and Histology, Department of Neurosciences, Biomedicine and Movement Sciences, School of Medicine, University of Verona, Verona, Italy.
Marina PizziDivision of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-motor symptoms are frequently observed in Parkinson's disease (PD) and precede the onset of motor deficits by years. Among them, neuropsychiatric symptoms, including anxiety, depression, and apathy, are increasingly considered as a major challenge for patients with PD and their caregivers. We recently reported that mice lacking the nuclear factor-κB (NF-κB)/c-Rel protein (c-rel

Indexed as

anxietyapathydepressionmouse modelNF-κB/c-Relnon-motor symptomsParkinson’s disease

Identifiers

PMID35368305
PMCPMC8965703

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.