Evidence map›Paper›PMID 35368287›Full record

ArticleFrontiers in neuroscience2022

Bone Mineral Density and Current Bone Health Screening Practices in Friedreich's Ataxia.

Julia Dunn, Jaclyn Tamaroff, Anna DeDio, Sara Nguyen, Kristin Wade, Nicolette Cilenti, David R Weber, David R Lynch, Shana E McCormack

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Observational
  3. Friedreich ataxia: clinical features and new developments.Neurodegenerative disease management · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Julia DunnDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Jaclyn TamaroffDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Anna DeDioDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Sara NguyenDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Kristin WadeDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Nicolette CilentiDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
David R WeberDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
David R LynchDivision of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Shana E McCormackDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · USVanderbilt University Medical Center · US

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
NAD+ precursor supplementation with exercise training to improve aerobic capacity in Friedreich's AtaxiaR01HL149722 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI MCCORMACK, SHANA ERIN · 2020 to 2024
$4.0M
Translational investigation of abnormal fat metabolism in mitochondrial diseaseK23DK102659 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI MCCORMACK, SHANA ERIN · 2015 to 2017
$515k
Glycemia and Cardiac Involvement in Friedreich's AtaxiaF32DK128970 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TAMAROFF, JACLYN · 2021 to 2022
$172k
NCATS NIH HHS UL1 TR001878NHLBI NIH HHS R01 HL149722NIDDK NIH HHS F32 DK128970NIDDK NIH HHS K23 DK102659
6 · The paper itself

Abstract

Introduction: Friedreich's Ataxia (FRDA) is a progressive neurological disorder caused by mutations in both alleles of the Methods: Dual energy X-ray absorptiometry (DXA) scan-based assessments of areal bone mineral density (aBMD) in individuals with FRDA were abstracted from four studies at the Children's Hospital of Philadelphia (CHOP). Disease outcomes, including the modified FRDA Rating Scale (mFARS), were abstracted from the FRDA Clinical Outcomes Measures Study (FACOMS), a longitudinal natural history study. A survey regarding bone health and fractures was sent to individuals in FACOMS-CHOP. Results: Adults with FRDA ( Conclusions: Low aBMD is prevalent in FRDA, but few of even the highest risk individuals are undergoing screening. Our findings highlight potential missed opportunities for the screening and treatment of low aBMD in FRDA.

Indexed as

bone healthbone mineral density–BMDfractures–boneFriedreich Ataxia (FRDA)mitochondria

Identifiers

PMID35368287
PMCPMC8964400
OpenAlexW4221087275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.