Evidence map›Paper›PMID 35368283›Full record

ArticleFrontiers in neuroscience2022

Altered Brain Function and Causal Connectivity Induced by Repetitive Transcranial Magnetic Stimulation Treatment for Major Depressive Disorder.

Muzhen Guan, Zhongheng Wang, Yanru Shi, Yuanjun Xie, Zhujing Ma, Zirong Liu, Junchang Liu, Xinyu Gao, Qingrong Tan, Huaning Wang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Distinct Biotypes of Visual Perception in Major Depressive Disorder.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Muzhen GuanDepartment of Mental Health, Xi'an Medical University, Xi'an, China.
Zhongheng WangDeptartment of Psychiatry, Xijing Hospital, Air Force Medical University, Xi'an, China.
Yanru ShiDeptartment of Psychiatry, Xijing Hospital, Air Force Medical University, Xi'an, China.
Yuanjun XieDepartment of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Zhujing MaDeptartment of Psychology, Air Force Medical University, Xi'an, China.
Zirong LiuDeptartment of Psychiatry, Yulin Fifth Hospital, Yuling, China.
Junchang LiuDeptartment of Psychiatry, Xijing Hospital, Air Force Medical University, Xi'an, China.
Xinyu GaoDeptartment of Psychology, Air Force Medical University, Xi'an, China.
Qingrong TanDeptartment of Psychiatry, Xijing Hospital, Air Force Medical University, Xi'an, China.
Huaning WangDeptartment of Psychiatry, Xijing Hospital, Air Force Medical University, Xi'an, China.
Xijing Hospital · CNAir Force Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Repetitive transcranial magnetic stimulation (rTMS) can effectively improve depression symptoms in patients with major depressive disorder (MDD); however, its mechanism of action remains obscure. This study explored the neuralimaging mechanisms of rTMS in improving depression symptoms in patients with MDD. Methods: In this study, MDD patients with first-episode, drug-naive ( Results: Before treatment, patients with MDD had significantly lower ALFF in the left superior frontal gyrus ( Conclusion: rTMS treatment not only improves the local neural activity in the middle frontal gyrus, superior frontal gyrus, and precuneus but also strengthens the bidirectional causal connectivity between the middle and superior frontal gyri and the causal connectivity from the inferior temporal to the middle frontal gyri. Changes in these neuroimaging indices may represent the neural mechanisms underlying rTMS treatment in MDD. Clinical Trial Registration: This study was registered in the Chinese Clinical Trial Registry (Registration number: ChiCTR1800019761).

Indexed as

amplitude of the low-frequency fluctuationGranger causality analysis (GCA)major depressive disorderregional homogeneityrepetitive transcranial magnetic stimulation

Identifiers

PMID35368283
PMCPMC8964457
OpenAlexW4221013756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.