Evidence map›Paper›PMID 35368264›Full record

ArticleFrontiers in neuroscience2022

Predicting Functional Connectivity From Observed and Latent Structural Connectivity

Jennifer A Cummings, Benjamin Sipes, Daniel H Mathalon, Ashish Raj

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Network Diffusion Modeling in Computational Neuroscience.Advances in experimental medicine and biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
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  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jennifer A CummingsDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States.
Benjamin SipesDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
Daniel H MathalonSan Francisco VA Medical Center, San Francisco, CA, United States.
Ashish RajDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States.

Funding

Understanding the dynamic interactions between tau pathology and microgliamediated inflammation in Alzheimer's DiseaseR01AG072753 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI BUTLER, TRACY A., GUPTA, AJAY · 2021 to 2025
$5.3M
Network Modelling of Multimodal Dynamics in Alzheimer’s Disease and DementiaRF1AG062196 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NAGARAJAN, SRIKANTAN S., RAJ, ASHISH · 2019 to 2019
$3.0M
Predictive model of spread of Parkinson's pathology using network diffusionR01NS092802 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GUPTA, AJAY, RAJ, ASHISH · 2016 to 2020
$2.8M
Understanding the dynamic interactions between tau pathology and microglia-mediated inflammation in Alzheimer's DiseaseR56AG064873 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI GUPTA, AJAY, RAJ, ASHISH · 2019 to 2019
$771k
NIA NIH HHS R01 AG072753NIA NIH HHS R56 AG064873NIA NIH HHS RF1 AG062196NINDS NIH HHS R01 NS092802
6 · The paper itself

Abstract

Understanding how complex dynamic activity propagates over a static structural network is an overarching question in the field of neuroscience. Previous work has demonstrated that linear graph-theoretic models perform as well as non-linear neural simulations in predicting functional connectivity with the added benefits of low dimensionality and a closed-form solution which make them far less computationally expensive. Here we show a simple model relating the eigenvalues of the structural connectivity and functional networks using the Gamma function, producing a reliable prediction of functional connectivity with a single model parameter. We also investigate the impact of local activity diffusion and long-range interhemispheric connectivity on the structure-function model and show an improvement in functional connectivity prediction when accounting for such latent variables which are often excluded from traditional diffusion tensor imaging (DTI) methods.

Indexed as

BOLD fMRIeigenvalue decompositionfunctional connectivityinter-hemispheric connectionsnetwork diffusion modelschizophreniaspectral graph theorystructural connectivity

Identifiers

PMID35368264
PMCPMC8964629

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.