Evidence map›Paper›PMID 35367939›Full record

ArticleDrug and alcohol dependence2022

Alcohol use and alcohol use disorder differ in their genetic relationships with PTSD: A genomic structural equation modelling approach.

Kaitlin E Bountress, Leslie A Brick, Christina Sheerin, Andrew Grotzinger, Daniel Bustamante, Sage E Hawn, Nathan Gillespie, Robert M Kirkpatrick, Henry Kranzler, Rajendra Morey and 15 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 17 institutions in 4 countries.

Kaitlin E BountressVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, USA. Electronic address: kaitlin.bountress@vcuhealth.org.
Leslie A BrickDepartment of Psychiatry and Human Behavior, Quantitative Sciences Program, Alpert Medical School at Brown University, USA.
Christina SheerinVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, USA.
Andrew GrotzingerBehavioral, Psychiatric, and Statistical Genetics, Institute for Behavior Genetics, University of Colorado Boulder, USA.
Daniel BustamanteVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, USA; Integrative Life Sciences Doctoral Program, Virginia Commonwealth University, USA.
Sage E HawnNational Center for PTSD at VA Boston Healthcare System, Boston, MA, USA; Boston University School of Medicine, Department of Psychiatry, Boston, MA, USA.
Nathan GillespieVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, USA.
Robert M KirkpatrickVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, USA.
Henry KranzlerUniversity of Pennsylvania Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA, USA; Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.
Rajendra MoreyVA Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham VAMC, Durham, NC, USA; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA; Duke-UNC Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.
Howard J EdenbergDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, USA; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, USA.
Adam X MaihoferDepartment of Psychiatry, University of California, San Diego, USA; Center of Excellence for Stress and Mental Health, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
Seth DisnerMinneapolis VA Health Care System, Minneapolis, MN, USA; Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
Allison Ashley-KochDuke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
Roseann PetersonVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, USA.
Adriana LoriDepartment of Psychiatry and Behavioral Sciences, Emory University, USA.
Dan J SteinDepartment of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Nathan KimbrelVA Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham VAMC, Durham, NC, USA; Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Caroline NievergeltDepartment of Psychiatry, University of California, San Diego, USA; Center of Excellence for Stress and Mental Health, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
Ole A AndreassenNORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Jurjen LuykxSchool for Mental Health and Neuroscience, Maastricht University Medical Centre, Department of Psychiatry and Neuropsychology Maastricht, The Netherlands; UMC Utrecht Brain Center, University Medical Center Utrecht, Department of Psychiatry Utrecht, University, Utrecht, The Netherlands; Outpatient second opinion clinic, GGNet Mental Health, Warnsveld, The Netherlands.
Arash JavanbakhtStress, Trauma, and Anxiety Research Clinic (STARC), Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.
Nagy A YoussefDepartment of Psychiatry and Behavioral Health, Ohio State University, Columbus, OH, USA.
Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group
Ananda B AmstadterVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, USA.
Virginia Commonwealth University · USDuke University · USBrown University · USDuke Medical Center · USEmory University · USIndiana University School of MedicineMinneapolis VA Health Care System · USNational Center for PTSD · USThe Ohio State University · USUniversity Medical Center Utrecht · NLUniversity of California, San Diego · USUniversity of Cape Town · ZAUniversity of Colorado Boulder · USUniversity of Oslo · NOUniversity of Pennsylvania · USVA San Diego Healthcare System · USWayne State University · US

Funding

Psychiatric Genomics Consortium for PTSDR01MH106595 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARESTAN C KOENEN, Caroline M Nievergelt · 2016 to 2026
$8.4M
Research Training: Psychiatric &Statistical GeneticsT32MH020030 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HERMINE H MAES, MICHAEL CHURTON NEALE · 1999 to 2026
$6.7M
Program Development and Pilot CoreP30AG066614 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI DEBRA J. UMBERSON · 2020 to 2026
$5.2M
Postdoctoral Training Program in Stress and TraumaT32MH019836 · NIMH · TUFTS UNIVERSITY BOSTON · PI DENISE M. SLOAN · 1996 to 2026
$4.7M
Trauma and Genomics Modulate Brain Structure across Common Psychiatric DisordersR01MH111671 · NIMH · DUKE UNIVERSITY · PI MARK W LOGUE, RAJENDRA A MOREY · 2017 to 2026
$4.4M
Cross-Population Working Group on Genes and Environment in Major Depression (POP-GEM): Advancing the Understating of Etiology through DiversityR01MH125938 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI Roseann Elizabeth Peterson · 2022 to 2026
$4.2M
Dissecting the Multivariate Genetic Architecture of Psychiatric DiseasesR01MH120219 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI NIVARD, MICHEL GUILLAUME, TUCKER-DROB, ELLIOT MAX · 2020 to 2024
$3.3M
7/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109532 · NIMH · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA, EDENBERG, HOWARD J · 2016 to 2020
$3.1M
Large-Scale Genomic Analysis of Aging-Related Cognitive Change Prior to Dementia OnsetRF1AG073593 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI TUCKER-DROB, ELLIOT MAX · 2021 to 2021
$2.1M
4/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124847 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIEVERGELT, CAROLINE M, SEBAT, JONATHAN · 2021 to 2025
$2.1M
Overlap in genetic and learning-based mechanisms for alcohol use disorder and posttraumatic stress disorderK01AA025692 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI SHEERIN-SMITH, CHRISTINA M · 2018 to 2022
$931k
Alcohol Use Phenotypes and Posttraumatic Stress Disorder: Investigating Shared Genetic, Behavioral, and Psychophysiological Risk FactorsK01AA028058 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI BOUNTRESS, KAITLIN ELIZABETH · 2020 to 2024
$876k
NIAAA NIH HHS K01 AA025692NIAAA NIH HHS K01 AA028058NIA NIH HHS P30 AG066614NIA NIH HHS RF1 AG073593NIMH NIH HHS K01 MH113848NIMH NIH HHS R01 MH106595NIMH NIH HHS R01 MH111671NIMH NIH HHS R01 MH120219NIMH NIH HHS R01 MH124847NIMH NIH HHS R01 MH125938NIMH NIH HHS T32 MH019836NIMH NIH HHS T32 MH020030NIMH NIH HHS U01 MH109532RRD VA IK2 RX002922
6 · The paper itself

Abstract

purposePosttraumatic Stress Disorder (PTSD) is associated with increased alcohol use and alcohol use disorder (AUD), which are all moderately heritable. Studies suggest the genetic association between PTSD and alcohol use differs from that of PTSD and AUD, but further analysis is needed. BASIC PROCEDURES: We used genomic Structural Equation Modeling (genomicSEM) to analyze summary statistics from large-scale genome-wide association studies (GWAS) of European Ancestry participants to investigate the genetic relationships between PTSD (both diagnosis and re-experiencing symptom severity) and a range of alcohol use and AUD phenotypes. MAIN

findingsWhen we differentiated genetic factors for alcohol use and AUD we observed improved model fit relative to models with all alcohol-related indicators loading onto a single factor. The genetic correlations (rG) of PTSD were quite discrepant for the alcohol use and AUD factors. This was true when modeled as a three-correlated-factor model (PTSD-AUD rG:.36, p < .001; PTSD-alcohol use rG: -0.17, p < .001) and as a Bifactor model, in which the common and unique portions of alcohol phenotypes were pulled out into an AUD-specific factor (rG with PTSD:.40, p < .001), AU-specific factor (rG with PTSD: -0.57, p < .001), and a common alcohol factor (rG with PTSD:.16, NS). PRINCIPAL

conclusionsThese results indicate the genetic architecture of alcohol use and AUD are differentially associated with PTSD. When the portions of variance unique to alcohol use and AUD are extracted, their genetic associations with PTSD vary substantially, suggesting different genetic architectures of alcohol phenotypes in people with PTSD.

Indexed as

AlcoholismStress Disorders, Post-TraumaticAlcohol DrinkingGenome-Wide Association StudyHumansLatent Class AnalysisAlcohol useAlcohol use disorderGenetic architectureGenetic correlationGenomic structural equation modeling (genomicSEM)Posttraumatic stress disorder (PTSD)

Identifiers

PMID35367939
PMCPMC9018560
OpenAlexW4220656712

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.