ArticleEBioMedicine2022
Telomere-length dependent T-cell clonal expansion: A model linking ageing to COVID-19 T-cell lymphopenia and mortality.
Article in EBioMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Telomere length and chronological age across the human lifespan: A systematic review and meta-analysis of 414 study samples including 743,019 individuals.Ageing research reviews · 2023Pooled it
- The neutrophil-to-lymphocyte ratio as a marker of immunosenescence and COVID-19 outcomes in the elderly: A narrative review.Physiological reports · 2026Review
- Telomere length and COVID-19 disease severity: insights from hospitalized patients.Frontiers in aging · 2025Article
- Exploring the Relationship between Telomere Length and Cognitive Changes in Post-COVID-19 Subjects.Biomedicines · 2024Article
- T-cell count and T-cell telomere length in patients with severe COVID-19.Frontiers in immunology · 2024Article
- Age-associated changes in innate and adaptive immunity: role of the gut microbiota.Frontiers in immunology · 2024Review
- Article
- Associations of telomere length with risk of mortality from influenza and pneumonia in US adults: a prospective cohort study of NHANES 1999-2002.Aging clinical and experimental research · 2023Article
- The Diagnostic, Prognostic, and Therapeutic Potential of Cell-Free DNA with a Special Focus on COVID-19 and Other Viral Infections.International journal of molecular sciences · 2023Review
- Article
- Enzymatic approaches against SARS-CoV-2 infection with an emphasis on the telomere-associated enzymes.Biotechnology letters · 2023Review
- Article
- Understanding Long COVID; Mitochondrial Health and Adaptation-Old Pathways, New Problems.Biomedicines · 2022Review
- Relationship of Covid-19 Severity with SARS-CoV-2 NS8 Protein Mutations Depending on Virus Strain.Doklady. Biochemistry and biophysics · 2022Article
- The bullwhip effect, T-cell telomeres, and SARS-CoV-2.The lancet. Healthy longevity · 2022Review
- Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons.Immunity & ageing : I & A · 2022Article
- Analysis of Relative Average Length of Telomeres in Leukocytes of Women with COVID-19.Cytology and genetics · 2022Article
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundSevere COVID-19 T-cell lymphopenia is more common among older adults and entails poor prognosis. Offsetting the decline in T-cell count during COVID-19 demands fast and massive T-cell clonal expansion, which is telomere length (TL)-dependent.
methodsWe developed a model of TL-dependent T-cell clonal expansion capacity with age and virtually examined the relation of T-cell clonal expansion with COVID-19 mortality in the general population.
findingsThe model shows that an individual with average hematopoietic cell TL (HCTL) at age twenty years maintains maximal T-cell clonal expansion capacity until the 6th decade of life when this capacity rapidly declines by more than 90% over the next ten years. The collapse in the T-cell clonal expansion capacity coincides with the steep increase in COVID-19 mortality with age.
interpretationShort HCTL might increase vulnerability of many older adults, and some younger individuals with inherently short HCTL, to COVID-19 T-cell lymphopenia and severe disease.
fundingA full list of funding bodies that contributed to this study can be found in the Acknowledgements section.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.