ArticleActa biomaterialia2022
Improved biocompatibility of Zn-Ag-based stent materials by microstructure refinement.
Article in Acta biomaterialia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Structural Optimization and Finite Element Analysis of Variable-Stiffness Biodegradable Vascular Stents.Journal of functional biomaterials · 2026Article
- Strut Thickness and Species-Specific Healing Are Key Considerations in Developing Zinc-Based Biodegradable Arterial Stents.Journal of biomedical materials research. Part B, Applied biomaterials · 2026Article
- Effect of Melt Spinning on Microstructure and Corrosion Uniformity of Zn-Ag-based Alloy.Journal of alloys and compounds · 2026Article
- Simultaneously improve mechanical properties and osteogenic properties of biodegradable Zn alloys by refining grain sizes to sub-micrometers.Scientific reports · 2026Article
- Mg-Y-Nd alloy biocorrosion behavior in hyperlipidemia models in vitro and in vivo.Acta biomaterialia · 2026Article
- Insights into the biological effects of molybdenum in an insect model (Frontiers in bioengineering and biotechnology · 2026Article
- Enhancement of mechanical, corrosion, and biocompatibility properties of zinc alloys through magnesium and neodymium alloying for bone implant applications.RSC advances · 2025Article
- Substantial improvement of mechanical properties of Zn-Mg alloys to orthopedic implants via rotary swaging.Scientific reports · 2025Article
- Effect of Combined Equal-Channel Angular Pressing and Rolling on the Microstructure and Mechanical Properties of Zn-0.5Ag-0.2Mg Alloy.Materials (Basel, Switzerland) · 2025Article
- The biological effects of copper alloying in Zn-based biodegradable arterial implants.Biomaterials advances · 2025Article
- MicroCT and contrast-enhanced microCT to study the in vivo degradation behavior and biocompatibility of candidate metallic intravascular stent materials.Acta biomaterialia · 2025Article
- Progress in research and development of biodegradable metallic vascular stents.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Review
- Thrombogenicity of biodegradable metals.Bioactive materials · 2024Article
- The influence of age on the biological response to biodegradable zinc arterial implants.Materialia · 2024Article
- Naphthalene Diimide-Based Metallacage as an Artificial Ion Channel for Chloride Ion Transport.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Insights into the biocompatibility of biodegradable metallic molybdenum for cardiovascular applications-a critical review.Frontiers in bioengineering and biotechnology · 2024Review
- Absorbable metal stents for vascular use in pediatric cardiology: progress and outlook.Frontiers in cardiovascular medicine · 2024Review
- Biocompatibility Assessment of Zinc Alloys as a New Potential Material for Bioabsorbable Implants for Osteosynthesis.Materials (Basel, Switzerland) · 2023Article
- Development, Processing and Aging of Novel Zn-Ag-Cu Based Biodegradable Alloys.Materials (Basel, Switzerland) · 2023Article
- Bioresorbable vascular metallic scaffolds: Current status and research trends.Current opinion in biomedical engineering · 2022Article
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
The metallurgical engineering of bioresorbable zinc (Zn)-based medical alloys would greatly benefit from clarification of the relationships between material properties and biological responses. Here we investigate the biocompatibility of three Zn-based silver (Ag)-containing alloys, ranging from binary to quinary alloy systems. Selected binary and quinary Zn-Ag-based alloys underwent solution treatment (ST) to increase the solubility of Ag-rich phases within the Zn bulk matrix, yielding two different microstructures (one without ST and a different one with ST) with the same elemental composition. This experimental design was intended to clarify the relationship between elemental profile/microstructure and biocompatibility for the Zn-Ag system. We found that the quinary alloy system (Zn-4Ag-0.8Cu-0.6Mn-0.15Zr) performed significantly better, in terms of histomorphometry, than any alloy system we have evaluated to date. Furthermore, when solution treated to increase strength and ductility and reduce the fraction of Ag-rich phases, the quinary alloy's biocompatibility further improved. In vitro corrosion testing and metallographic analysis of in vivo implants demonstrated a more uniform mode of corrosion for the solution treated alloy. We conclude that Zn-Ag alloys can be engineered through alloying to substantially reduce neointimal growth. The positive effect on neointimal growth can be further enhanced by dissolving the AgZn
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