Evidence map›Paper›PMID 35367616›Full record

Trial reportPhotodiagnosis and photodynamic therapy2022

Clinical evaluation of a mobile, low-cost system for fluorescence guided photodynamic therapy of early oral cancer in India.

Shahid Ali Siddiqui, Shaista Siddiqui, M A Bilal Hussain, Shakir Khan, Hui Liu, Kafil Akhtar, Syed Abrar Hasan, Ibne Ahmed, Srivalleesha Mallidi, Amjad P Khan and 5 more

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Photodiagnosis and photodynamic therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06876038 (A Comprehensive Platform for Low-cost Screening and Image-guided Photodynamic Therapy), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06876038 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Comprehensive Platform for Low-cost Screening and Image-guided Photodynamic Therapy (PDT) Treatment of Pre-malignant and Malignant Oral Lesions in Low-resource Setting

TypeinterventionalSponsorUniversity of Massachusetts, BostonRan2026 to 2028Enrolled65ConditionsOral Cancer, Oral Cavity Cancer, Oral Leukoplakia, Oral Lichen PlanusArms5-Amino Levulinic Acid
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Shahid Ali SiddiquiAligarh Muslim University, Jawaharlal Nehru Medical College, Department of Radiotherapy, Aligarh, India.
Shaista SiddiquiAligarh Muslim University, Jawaharlal Nehru Medical College, Department of Radiodiagnosis, Aligarh, India.
M A Bilal HussainAligarh Muslim University, Jawaharlal Nehru Medical College, Department of Radiotherapy, Aligarh, India.
Shakir KhanAligarh Muslim University, Jawaharlal Nehru Medical College, Department of Radiotherapy, Aligarh, India; University of Massachusetts at Boston, Boston, MA, United States; Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States.
Hui LiuUniversity of Massachusetts at Boston, Boston, MA, United States.
Kafil AkhtarAligarh Muslim University, Jawaharlal Nehru Medical College, Department of Pathology, Aligarh, India.
Syed Abrar HasanAligarh Muslim University, Jawaharlal Nehru Medical College, Department of Otorhinolaryngology (E.N.T.), Aligarh, India.
Ibne AhmedAligarh Muslim University, Jawaharlal Nehru Medical College, Department of Radiodiagnosis, Aligarh, India.
Srivalleesha MallidiMassachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States.
Amjad P KhanMassachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States.
Filip CuckovWentworth Institute of Technology, Boston, Massachusetts, United States.
Colin HopperUniversity College London, England.
Stephen BownUniversity College London, England.
Jonathan P CelliUniversity of Massachusetts at Boston, Boston, MA, United States; Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States.
Tayyaba HasanMassachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States; Division of Health Sciences and Technology, Harvard University and Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: thasan@mgh.harvard.edu.
Jawaharlal Nehru Medical College Hospital · INHarvard University · USUniversity College London · GBMassachusetts General Hospital · USRagon Institute of MGH, MIT and Harvard · USUniversity of Massachusetts Boston · USWentworth Institute of Technology · US

Funding

Low-cost Enabling Technology for Image-guided Photodynamic Therapy (PDT) of OralUH3CA189901 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CELLI, JONATHAN P, HASAN, TAYYABA · 2016 to 2019
$2.7M
Low-cost Enabling Technology for Image-guided Photodynamic Therapy (PDT) of OralUH2CA189901 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CELLI, JONATHAN P, HASAN, TAYYABA · 2014 to 2015
$995k
NCI NIH HHS UH2 CA189901NCI NIH HHS UH3 CA189901
6 · The paper itself

Abstract

backgroundMorbidity and mortality due to oral cancer in India are exacerbated by a lack of access to effective treatments amongst medically underserved populations. We developed a user-friendly low-cost, portable fibre-coupled LED system for photodynamic therapy (PDT) of early oral lesions, using a smartphone fluorescence imaging device for treatment guidance, and 3D printed fibreoptic attachments for ergonomic intraoral light delivery.

methods30 patients with T

findingsThere were no significant complications or discomfort. No sedation was required. No residual disease was detected in 22 out of 30 patients who completed the study (26 of 34 lesions, 76% complete tumour response, 50 weeks median follow-up) with up to 7.2 mm depth of necrosis. Treatment failures were attributed to large tumour size and/or inadequate light delivery (documented by limited photobleaching). Moderately differentiated lesions were more responsive than well-differentiated cancers.

interpretationThis simple and low-cost adaptation of fluorescenceguided PDT is effective for treatment of early-stage malignant oral lesions and may have implications in global health.

Indexed as

Mouth NeoplasmsPhotochemotherapyAminolevulinic AcidHumansIndiaPhotosensitizing AgentsAminolevulinic AcidPhotosensitizing AgentsEarly Oral CancerFluorescenceIndiaLow-cost treatmentPDTPhotodynamic Therapy

Identifiers

PMID35367616
PMCPMC9177774
OpenAlexW4221062614

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.