Evidence map›Paper›PMID 35367470›Full record

ArticleThe Journal of allergy and clinical immunology2022

Epithelial cell responses to rhinovirus identify an early-life-onset asthma phenotype in adults.

Eugene H Chang, Nima Pouladi, Stefano Guerra, Jana Jandova, Alexander Kim, Haiquan Li, Jianrong Li, Wayne Morgan, Debra A Stern, Amanda L Willis and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Eugene H ChangDepartment of Otolaryngology, Tucson, Ariz; College of Medicine, Tucson, Ariz; Asthma/Airway Disease Research Center, Tucson, Ariz; University of Arizona BIO5 Institute, University of Arizona, Tucson, Ariz. Electronic address: echang@oto.arizona.edu.
Nima PouladiDepartment of Biomedical Informatics, the University of Utah School of Medicine, Salt Lake City, Utah.
Stefano GuerraCollege of Medicine, Tucson, Ariz; Asthma/Airway Disease Research Center, Tucson, Ariz; University of Arizona BIO5 Institute, University of Arizona, Tucson, Ariz.
Jana JandovaDepartment of Otolaryngology, Tucson, Ariz.
Alexander KimDepartment of Otolaryngology, Tucson, Ariz.
Haiquan LiUniversity of Arizona BIO5 Institute, University of Arizona, Tucson, Ariz.
Jianrong LiDepartment of Biomedical Informatics, the University of Utah School of Medicine, Salt Lake City, Utah.
Wayne MorganCollege of Medicine, Tucson, Ariz; Asthma/Airway Disease Research Center, Tucson, Ariz; University of Arizona BIO5 Institute, University of Arizona, Tucson, Ariz.
Debra A SternCollege of Medicine, Tucson, Ariz; Asthma/Airway Disease Research Center, Tucson, Ariz; University of Arizona BIO5 Institute, University of Arizona, Tucson, Ariz.
Amanda L WillisDepartment of Otolaryngology, Tucson, Ariz.
Yves A LussierDepartment of Biomedical Informatics, the University of Utah School of Medicine, Salt Lake City, Utah.
Fernando D MartinezCollege of Medicine, Tucson, Ariz; Asthma/Airway Disease Research Center, Tucson, Ariz; University of Arizona BIO5 Institute, University of Arizona, Tucson, Ariz.
University of Arizona · USTucson Medical Center · USUniversity of Utah · US

Funding

Early Origins of Chronic Lung Disease: Outcomes into the Fifth Decade of LifeR01HL132523 · NHLBI · UNIVERSITY OF ARIZONA · PI Stefano Guerra, Fernando D Martinez · 2016 to 2026
$15.1M
Interactions between RV-C and its receptor CDHR3 in the development of chronic rhinosinusitisR01AI146131 · NIAID · UNIVERSITY OF ARIZONA · PI CHANG, EUGENE H · 2020 to 2023
$2.2M
NHLBI NIH HHS R01 HL132523NIAID NIH HHS R01 AI146131
6 · The paper itself

Abstract

backgroundThe study of pathogenic mechanisms in adult asthma is often marred by a lack of precise information about the natural history of the disease. Children who have persistent wheezing (PW) during the first 6 years of life and whose symptoms start before age 3 years (PW

objectiveOur aim was to determine whether nasal epithelial cells from PW

methodsAir-liquid interface cultures derived from nasal epithelial cells of 36-year old participants with active asthma with and without a history of PW in childhood (10 PW

resultsA total of 35 differentially expressed genes involved in extracellular remodeling and angiogenesis distinguished the PW

conclusionsAsthmatic adults with a history of persistent wheeze in the first 6 years of life have specific biomolecular alterations in response to RV-A that are not present in patients without such a history. Targeting these mechanisms may slow the progression of asthma in these patients.

Indexed as

AsthmaEnterovirus InfectionsPicornaviridae InfectionsAdultChildChild, PreschoolEpithelial CellsHumansPhenotypeRespiratory SoundsRhinovirusairway remodelingapoptosisblood vessel remodelingEarly-onset childhood asthmainterleukin responsepersistent wheezeprotein processingrhinovirusRNA sequencingToll-like receptor pathwaystranscriptome

Identifiers

PMID35367470
PMCPMC9463086
OpenAlexW4225253433

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.