Evidence map›Paper›PMID 35367417›Full record

ArticleExperimental eye research2022

Age and sex affect TGFβ2-induced ocular hypertension in C57BL/6J mice.

Chenna Kesavulu Sugali, Naga Pradeep Rayana, Jiannong Dai, Michael Peng, Weiming Mao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. The Inducible TGFβ2 Ocular Hypertension Mouse Model.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chenna Kesavulu SugaliEugene & Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, USA.
Naga Pradeep RayanaEugene & Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, USA.
Jiannong DaiEugene & Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, USA.
Michael PengEugene & Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, USA.
Weiming MaoEugene & Marilyn Glick Eye Institute, Department of Ophthalmology, Indiana University School of Medicine, USA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, USA; Department of Pharmacology and Toxicology, Indiana University School of Medicine, USA. Electronic address: weimmao@iu.edu.
Indiana University School of Medicine

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
The role of Wnt signaling in treating glucocorticoid-induced glaucomaR01EY031700 · NEI · INDIANA UNIVERSITY INDIANAPOLIS · PI MAO, WEIMING · 2021 to 2025
$2.5M
Cross-talk between TGF-beta and Wnt pathways in the trabecular meshworkR01EY026962 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI MAO, WEIMING · 2017 to 2021
$1.9M
NCATS NIH HHS UL1 TR002529NEI NIH HHS R01 EY026962NEI NIH HHS R01 EY031700
6 · The paper itself

Abstract

Glaucoma is a leading cause of blindness worldwide. The loss of vision in glaucoma patients is due to optic nerve damage. The most important risk factor of glaucoma is elevated intraocular pressure (IOP) which is due to glaucomatous changes in the trabecular meshwork. Animal models, especially mouse models for ocular hypertension (OHT), are important for studying glaucoma. Published studies showed that 2.5 × 10

Indexed as

GlaucomaOcular HypertensionAnimalsDisease Models, AnimalFemaleHumansIntraocular PressureMaleMiceMice, Inbred C57BLTonometry, OcularTrabecular MeshworkTransforming Growth Factor beta2Transforming Growth Factor beta2GlaucomaIntraocular pressureMouse modelOcular hypertensionTGFβ2

Identifiers

PMID35367417
PMCPMC9176402
OpenAlexW4220924484

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.