ArticleClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases2022
Impact of COVID-19 and malaria coinfection on clinical outcomes: a retrospective cohort study.
Article in Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- COVID-19 and malaria co-infection: a systematic review of clinical outcomes in endemic areas.PeerJ · 2024Pooled it
- Monocellular and Multicellular Parasites Infesting Humans: A Review of Calcium Ion Mechanisms.Biomedicines · 2025Review
- Mortality and associated factors among hospitalised COVID-19 patients in Lira regional referral hospital, a cross-sectional study.BMJ open · 2025Article
- Circulation of SARS-CoV-2 and Co-Infection withInfectious disease reports · 2025Article
- Impact of co-infection with Plasmodium berghei ANKA in Leishmania major-parasitized mice on immune modulation and cutaneous leishmaniasis.PLoS neglected tropical diseases · 2025Article
- Coinfection of COVID-19 and malaria: clinical profiles, interactions, and strategies for effective control.Malaria journal · 2025Review
- Article
- Biogenically synthesized green silver nanoparticles exhibit antimalarial activity.Discover nano · 2024Article
- Incidence of Helminthic and Viral Coinfections in Malaria Patients in the Tertiary Care Hospital Setup.Journal of tropical medicine · 2024Article
- Coronavirus disease 2019 and malaria coinfection in a middle-aged Ethiopian woman presenting with acute febrile illness and bilateral pleural effusion: a case report.Journal of medical case reports · 2023Article
- Co-infection of COVID-19 and parasitic diseases: A systematic review.Parasite epidemiology and control · 2023Review
- Review
- Plasmodium vivax and SARS-CoV-2 co-infection in Venezuelan pregnant women: a case series.Malaria journal · 2023Article
- Malaria and COVID-19 coinfection in a non-malaria-endemic area in Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2023Article
- SARS-CoV-2 decreases malaria severity in co-infected rodent models.Frontiers in cellular and infection microbiology · 2023Article
- Profiles of host immune impairment inHeliyon · 2022Review
- Survival analysis of patients with COVID-19 admitted at six hospitals in Uganda in 2021: a cohort study.Archives of public health = Archives belges de sante publique · 2022Article
- Co-Infection withTropical medicine and infectious disease · 2022Article
- Protozoan co-infections and parasite influence on the efficacy of vaccines against bacterial and viral pathogens.Frontiers in microbiology · 2022Review
- Malaria and COVID-19 prevalence in a population of febrile children and adolescents living in Libreville.Southern African journal of infectious diseases · 2022Article
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesDespite the possibility of concurrent infection with COVID-19 and malaria, little is known about the clinical course of coinfected patients. We analysed the clinical outcomes of patients with concurrent COVID-19 and malaria infection.
methodsWe conducted a retrospective cohort study that assessed prospectively collected data of all patients who were admitted between May and December 2020 to the Universal COVID-19 treatment center (UCTC), Khartoum, Sudan. UCTC compiled demographic, clinical, laboratory (including testing for malaria), and outcome data in all patients with confirmed COVID-19 hospitalized at that clinic. The primary outcome was all-cause mortality during the hospital stay. We built proportional hazard Cox models with malaria status as the main exposure and stepwise adjustment for age, sex, cardiovascular comorbidities, diabetes, and hypertension.
resultsWe included 591 patients with confirmed COVID-19 diagnosis who were also tested for malaria. Mean (SD) age was 58 (16.2) years, 446/591 (75.5%) were males. Malaria was diagnosed in 270/591 (45.7%) patients. Most malaria patients were infected by Plasmodium falciparum (140/270; 51.9%), while 121/270 (44.8%) were coinfected with Plasmodium falciparum and Plasmodium vivax. Median follow-up was 29 days. Crude mortality rates were 10.71 and 5.87 per 1000 person-days for patients with and without concurrent malaria, respectively. In the fully adjusted Cox model, patients with concurrent malaria and COVID-19 had a greater mortality risk (hazard ratio 1.43, 95% confidence interval 1.21-1.69). DISCUSSION: Coinfection with COVID-19 and malaria is associated with increased all-cause in-hospital mortality compared to monoinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
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