Evidence map›Paper›PMID 35367208›Full record

ArticleThe Journal of biological chemistry2022

Proteomic elucidation of the targets and primary functions of the picornavirus 2A protease.

Artem A Serganov, Yael Udi, Milana E Stein, Valay Patel, Peter C Fridy, Charles M Rice, Mohsan Saeed, Erica Y Jacobs, Brian T Chait, Michael P Rout

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Artem A SerganovLaboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York, USA.
Yael UdiLaboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York, USA. Electronic address: yudi@rockefeller.edu.
Milana E SteinLaboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York, USA.
Valay PatelLaboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York, USA.
Peter C FridyLaboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York, USA.
Charles M RiceLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York, USA.
Mohsan SaeedLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York, USA; Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, USA; National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston University, Massachusetts, USA. Electronic address: msaeed1@bu.edu.
Erica Y JacobsLaboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York, USA; Chemistry Department, St John's University, Queens, New York, USA. Electronic address: jacobse@stjohns.edu.
Brian T ChaitLaboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York, USA. Electronic address: chait@rockefeller.edu.
Michael P RoutLaboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York, USA. Electronic address: rout@rockefeller.edu.
Rockefeller University · USBoston University · USSt. John's University · US

Funding

TR&D Project 4. The Imaging Stage: Multiscale Spatiotemporal Modeling of Macromolecular Systems in Cellular NeighborhoodsP41GM109824 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2014 to 2023
$18.8M
Structure-Function Mapping of the Nuclear Pore Complex-RenewalR01GM112108 · NIGMS · ROCKEFELLER UNIVERSITY · PI JOHN D. AITCHISON, MICHAEL P ROUT · 2015 to 2026
$9.1M
Type I interferon-stimulated genes and the antiviral immune responseR01AI091707 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2011 to 2020
$5.5M
Altered Communication between the nucleus and the mitochondria under oncogenic statesR01CA228351 · NCI · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2019 to 2023
$1.9M
NCI NIH HHS R01 CA228351NIAID NIH HHS R01 AI091707NIGMS NIH HHS P41 GM109824NIGMS NIH HHS R01 GM112108
6 · The paper itself

Abstract

Picornaviruses are small RNA viruses that hijack host cell machinery to promote their replication. During infection, these viruses express two proteases, 2A

Indexed as

Peptide HydrolasesPicornaviridaeEukaryotic Initiation Factor-4GProteomicsRNA, MessengerEukaryotic Initiation Factor-4GPeptide HydrolasesRNA, Messengermass spectrometrynuclear porenuclear transportpicornavirusplus-stranded RNA virusproteaseproteomics

Identifiers

PMID35367208
PMCPMC9168619
OpenAlexW4220729596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.