Observational studyFertility and sterility2022
Presurgical blood metabolites and risk of postsurgical pelvic pain in young patients with endometriosis.
Observational study in Fertility and sterility, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- A systematic review of physical activity-based interventions to prevent or reduce chronic post-surgical pain.Pain medicine (Malden, Mass.) · 2026Pooled it
- Serum metabolic fingerprinting for diagnosis and therapeutic applications of ovarian endometriosis.iScience · 2026Article
- Endometriosis phenotypes and staging in relation to lipid biomarkers: Findings from the ENDO Cohort Study.Journal of gynecology obstetrics and human reproduction · 2026Article
- Plasma metabolites associated with endometriosis in adolescents and young adults.Human reproduction (Oxford, England) · 2025Article
- Innovations in acute and chronic pain biomarkers: enhancing diagnosis and personalized therapy.Regional anesthesia and pain medicine · 2025Review
- The Current Applications of Metabolomics in Understanding Endometriosis: A Systematic Review.Metabolites · 2025Review
- Impact of gut microbiota on endometriosis: linking physical injury to mental health.Frontiers in cellular and infection microbiology · 2025Review
- Serum Metabolites as Diagnostic Biomarkers in Patients with Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- A novel cortical biomarker signature predicts individual pain sensitivity.medRxiv : the preprint server for health sciences · 2024Article
- Article
- Bidirectional causality between the levels of blood lipids and endometriosis: a two-sample mendelian randomization study.BMC women's health · 2024Article
- An overview and comprehensive analysis of interdisciplinary clinical research in endometriosis based on trial registry.iScience · 2024Article
- Investigating the causal effect of various metabolites on postherpetic neuralgia: a Mendelian randomization study.Frontiers in neurology · 2024Article
- Assessing the Genetic Causal Effects Between Blood Metabolites and Spinal Pain: A Bidirectional Two-Sample Mendelian Randomization Study.Journal of pain research · 2024Article
- Plasma proteomic profiles of pain subtypes in adolescents and young adults with endometriosis.Human reproduction (Oxford, England) · 2023Article
- An insight into gut microbiota and metabolites in the mice with adenomyosis.Frontiers in cellular and infection microbiology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo identify metabolites in presurgical blood associated with risk of persistent postsurgical pelvic pain 1 year after endometriosis surgery in adolescent and young adult patients.
designProspective observational study within the Women's Health Study: From Adolescence to Adulthood, a US-based longitudinal cohort of adolescents and women enrolled from 2012-2018.
settingTwo tertiary care hospitals. PATIENT(S): Laparoscopically confirmed endometriosis patients (n = 180) with blood collected before their endometriosis surgery. Of these, 77 patients additionally provided blood samples 5 weeks to 6 months after their surgery. We measured plasma metabolites using liquid chromatography tandem mass spectrometry, and a total of 390 known metabolites were included in our analysis. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Persistent postsurgical pelvic pain, defined as severe, life-impacting pelvic pain 1 year after endometriosis surgery. RESULT(S): Most patients (>95%) were at stage I/II of the revised American Society for Reproductive Medicine classification. Their average age at diagnosis was 18.7 years, with 36% reporting persistent postsurgical pelvic pain. Of the 21 metabolites in presurgical blood that were associated with risk of persistent postsurgical pelvic pain, 19 metabolites, which were mainly lipid metabolites, were associated with increased risk. Only 2 metabolites-pregnenolone sulfate (odds ratio = 0.64, 95% confidence interval = 0.44-0.92) and fucose (odds ratio = 0.69, 95% confidence interval = 0.47-0.97)-were associated with decreased risk. Metabolite set enrichment analysis revealed that higher levels of lysophosphatidylethanolamines (false discovery rate = 0.01) and lysophosphatidylcholines (false discovery rate = 0.01) in presurgical blood were associated with increased risk of persistent postsurgical pelvic pain. CONCLUSION(S): Our results suggest that dysregulation of multiple groups of lipid metabolites may play a role in the persistence of pelvic pain postsurgery among young endometriosis patients.
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