ArticleMalaria journal2022
Accuracy of a rapid diagnosis test, microscopy and loop-mediated isothermal amplification in the detection of asymptomatic Plasmodium infections in Korhogo, Northern Côte d'Ivoire.
Article in Malaria journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- To what extent do people in malaria-endemic countries know asymptomatic malaria infections? A systematic review.PloS one · 2026Pooled it
- Uncovering silent malaria reservoirs in Southern Ethiopia: community-based molecular detection of asymptomatic and sub-microscopic infections and their implications for diagnosis and control.Malaria journal · 2026Article
- Diagnostic and therapeutic practices for paediatric malaria: Gap between guidelines and clinical reality in south-east Gabon.MalariaWorld journal · 2026Article
- Epidemiological Profile and Risk Factors for Malaria in Rural Communities Before the Operationalization of the Singrobo-Ahouaty Dam, Southern Côte d'Ivoire.Tropical medicine and infectious disease · 2025Article
- Asymptomatic malaria infections and associated risk factors in malaria-eliminating settings of Nong District, Savannakhet Province, Lao People's Democratic Republic.Tropical medicine and health · 2025Article
- Article
- Prospective acceptability of mass drug administration for malaria in Kedougou region in Senegal: a mixed method study.Malaria journal · 2024Article
- High prevalence of asymptomatic and subpatent Plasmodium falciparum infections but no histidine-rich protein 2 gene deletion in Bouaké, Côte d'Ivoire.Scientific reports · 2024Article
- Prevalence and predictors of asymptomatic malaria infection in Boricha District, Sidama Region, Ethiopia: implications for elimination strategies.Malaria journal · 2023Article
- Performance of antigen detection for HRP2-based malaria rapid diagnostic tests in community surveys: Tanzania, July-November 2017.Malaria journal · 2022Article
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13 authors at 5 institutions in 2 countries.
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Abstract
backgroundHighly sensitive and accurate malaria diagnostic tools are essential to identify asymptomatic low parasitaemia infections. This study evaluated the performance of histidine-rich protein 2 (HRP-2) based rapid diagnostic tests (RDTs), microscopy and loop-mediated isothermal amplification (LAMP) for the detection of asymptomatic Plasmodium spp. infections in Northern Côte d'Ivoire, using nested polymerase chain reaction (nPCR) as reference.
methodsA household-based survey was carried out in July 2016, in the health district of Korhogo, involving 1011 adults without malaria symptom nor history of fever during the week before recruitment. The fresh capillary blood samples were collected to detect Plasmodium infections using on HRP-2-based RDTs, microscopy and LAMP and stored as dried blood spots (DBS). A subset of the DBS (247/1011, 24.4%) was randomly selected for nPCR analyses. Additionally, venous blood samples, according to LAMP result (45 LAMP positive and 65 LAMP negative) were collected among the included participants to perform the nested PCR used as the reference.
resultsThe prevalence of asymptomatic Plasmodium spp. infections determined by RDT, microscopy, and LAMP were 4% (95% confidence interval (CI) 2.8-5.3), 5.2% (95% CI 3.9-6.6) and 18.8% (95% CI 16.4-21.2), respectively. Considering PCR on venous blood as reference, performed on 110 samples, the sensibility and specificity were, respectively, 17.8% (95% CI 6.1-29.4) and 100% for RDT, 20.0% (95% CI 7.8-32) and 100% for microscopy, and 93.3% (95% CI 85.7-100) and 95.4% (95% CI 92.2-100) for LAMP.
conclusionIn Northern Côte d'Ivoire, asymptomatic Plasmodium infection was found to be widely distributed as approximately one out of five study participants was found to be Plasmodium infected. LAMP appears currently to be the only available diagnostic method that can identify in the field this reservoir of infections and should be the method to consider for potential future active case detection interventions targeting elimination of these infections.
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