Observational studyBMC anesthesiology2022
ABO and RhD blood group are not associated with mortality and morbidity in critically ill patients; a multicentre observational study of 29 512 patients.
Observational study in BMC anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Comparative Evaluation of Feature Selection Strategies for ICU Mortality Prediction Using Chest Radiographic, Radiomic, and Demographic Features.Diagnostics (Basel, Switzerland) · 2026Article
- ABO/rhesus D blood systems and health indices: a preliminary study to find an association among healthy dwellers of Anuradhapura, Sri Lanka.BMC research notes · 2025Article
- ABO Blood Type and Short-Term Mortality in Patients With Infection-Associated Disseminated Intravascular Coagulation.European journal of haematology · 2025Article
- ABO blood type is not a risk factor of outcome in aneurysmal subarachnoid hemorrhage patients.European journal of medical research · 2024Article
- Modeling and predicting individual variation in COVID-19 vaccine-elicited antibody response in the general population.PLOS digital health · 2024Article
- Impact of COVID status and blood group on complications in patients in hemorrhagic shock.Trauma surgery & acute care open · 2024Article
- Blood group O is associated with ARDS development but exhibits lower mortality in the intensive care unit - A retrospective multicentre study.European clinical respiratory journal · 2024Article
- ABO blood group and link to COVID-19: A comprehensive review of the reported associations and their possible underlying mechanisms.Microbial pathogenesis · 2022Review
- Blood phenotype O and indirect bilirubin are associated with lower, early COVID-19-related mortality: A retrospective study.International journal of immunopathology and pharmacologyObservational
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ABO and RhD blood group represent antigens on the surface of erythrocytes. The ABO blood group antigens are also present on multiple other cells. Interestingly, previous studies have demonstrated associations between the blood group and many types of disease. The present study aimed to identifying associations between the ABO blood group, the RhD blood group, and morbidity and mortality in a mixed cohort and in six pre-defined subgroups of critically ill patients.
methodsAdult patients admitted to any of the five intensive care units (ICUs) in the Scania Region, Sweden, between February 2007 and April 2021 were eligible for inclusion. The outcomes were mortality analysed at 28- and 90-days as well as at the end of observation and morbidity measured using days alive and free of (DAF) invasive ventilation (DAF ventilation) and DAF circulatory support, including vasopressors or inotropes (DAF circulation), maximum Sequential Organ Failure Assessment score (SOFAmax) the first 28 days after admission and length of stay. All outcomes were analysed in separate multivariable regression models adjusted for age and sex. In addition, in a sensitivity analysis, five subgroups of patients with the main diagnoses sepsis, septic shock, acute respiratory distress syndrome, cardiac arrest and trauma were analysed using the same separate multivariable regression models.
resultsIn total, 29,512 unique patients were included in the analyses. There were no significant differences for any of the outcomes between non-O blood groups and blood group O, or between RhD blood groups. In the sensitivity analysis of subgroups, there were no differences in mortality between non-O blood groups and blood group O or between the RhD blood groups. AB was the most common blood group in the COVID-19 cohort.
conclusionsThe ABO and RhD blood group do not influence mortality or morbidity in a general critically ill patient population.
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