Evidence map›Paper›PMID 35366734›Full record

ArticleMolecular neurobiology2022

Amantadine Attenuated Hypoxia-Induced Mitochondrial Oxidative Neurotoxicity, Apoptosis, and Inflammation via the Inhibition of TRPM2 and TRPV4 Channels.

Özgür Öcal, Aymer Coşar, Mustafa Nazıroğlu

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Özgür ÖcalDepartment of Neurosurgery, Ankara City State Hospital, Ankara, Turkey.
Aymer CoşarDepartment of Neurosurgery, Polatlı Duatepe State Hospital, Ankara, Turkey.
Mustafa NazıroğluNeuroscience Research Center, Suleyman Demirel University, Isparta, Turkey. mustafanaziroglu@sdu.edu.tr.

Funding

BSN Health, Analyses, Innov., Consult., Org., Agricul., and Indust. Ltd., Isparta, Turkey 2019-06
6 · The paper itself

Abstract

The hypoxia (HPX) acts the brain injury and apoptosis via the Ca

Indexed as

Brain InjuriesNeurotoxicity SyndromesTRPM Cation ChannelsAmantadineApoptosisCalciumHEK293 CellsHumansHydrogen PeroxideHypoxiaInflammationOxidative StressReactive Oxygen SpeciesTRPV Cation ChannelsAmantadineCalciumHydrogen PeroxideReactive Oxygen SpeciesTRPM2 protein, humanTRPM Cation ChannelsTRPV4 protein, humanTRPV Cation ChannelsAmantadineCerebrovascular diseaseHypoxiaOxidative neurotoxicityTRPM2TRPV4

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.