ArticleJournal of the European Academy of Dermatology and Venereology : JEADV2022
Gut dysbiosis in cutaneous T-cell lymphoma is characterized by shifts in relative abundances of specific bacterial taxa and decreased diversity in more advanced disease.
Article in Journal of the European Academy of Dermatology and Venereology : JEADV, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Global Microbiome: Core and Unique Signatures Across Diverse Populations.International journal of molecular sciences · 2026Pooled it
- Characterization of the Gut Microbiota in Patients with Erythroderma.Acta dermato-venereologica · 2025Article
- Decreased gut short-chain fatty acids in cutaneous T-cell lymphoma: a novel insight.Archives of dermatological research · 2025Article
- Review
- Influence of the gut microbiome on lymphoma treatment: current evidence and future therapeutic directions.Therapeutic advances in medical oncology · 2025Review
- Role of Antigenic Stimulation in Cutaneous T-Cell Lymphomas.The Journal of investigative dermatology · 2024Review
- Chemical exposures and demographic associations in cutaneous T-cell lymphoma: a large single institution physician validated cohort study.Archives of dermatological research · 2024Article
- Cutaneous T-Cell Lymphoma and Microbiota: Etiopathogenesis and Potential New Therapeutic Targets.Dermatology research and practice · 2024Review
- Ionizing radiation improves skin bacterial dysbiosis in cutaneous T-cell lymphoma.Frontiers in immunology · 2024Article
- The causal relationship between gut microbiota and lymphoma: a two-sample Mendelian randomization study.Frontiers in immunology · 2024Article
- Role of the Microbiota in Skin Neoplasms: New Therapeutic Horizons.Microorganisms · 2023Review
- Gut microbiota analyses of cutaneous T-cell lymphoma patients undergoing narrowband ultraviolet B therapy reveal alterations associated with disease treatment.Frontiers in immunology · 2023Article
- Narrowband ultraviolet B response in cutaneous T-cell lymphoma is characterized by increased bacterial diversity and reducedFrontiers in immunology · 2022Article
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundCutaneous T-cell lymphoma (CTCL) patients often suffer from recurrent skin infections and profound immune dysregulation in advanced disease. The gut microbiome has been recognized to influence cancers and cutaneous conditions; however, it has not yet been studied in CTCL.
objectivesTo investigate the gut microbiome in patients with CTCL and in healthy controls.
methodsA case-control study was conducted between January 2019 and November 2020 at Northwestern's busy multidisciplinary CTCL clinic (Chicago, Illinois, USA) utilizing 16S ribosomal RNA gene amplicon sequencing and bioinformatics analyses to characterize the microbiota present in fecal samples of CTCL patients (n = 38) and age-matched healthy controls (n = 13) from the same geographical region.
resultsGut microbial α-diversity trended lower in patients with CTCL and was significantly lower in patients with advanced CTCL relative to controls (P = 0.015). No differences in β-diversity were identified. Specific taxa were significantly reduced in patient samples; significance was determined using adjusted P-values (q-values) that accounted for a false discovery rate threshold of 0.05. Significantly reduced taxa in patient samples included the phylum Actinobacteria (q = 0.0002), classes Coriobacteriia (q = 0.002) and Actinobacteria (q = 0.03), order Coriobacteriales (q = 0.003), and genus Anaerotruncus (q = 0.01). The families Eggerthellaceae (q = 0.0007) and Lactobacillaceae (q = 0.02) were significantly reduced in patients with high skin disease burden.
conclusionsGut dysbiosis can be seen in patients with CTCL compared to healthy controls and is pronounced in more advanced CTCL. The taxonomic shifts associated with CTCL are similar to those previously reported in atopic dermatitis and opposite those of psoriasis, suggesting microbial parallels to the immune profile and skin barrier differences between these conditions. These findings may suggest new microbial disease biomarkers and reveal a new angle for intervention.
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