ReviewMedical physics2022
A roadmap to clinical trials for FLASH.
Review in Medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 55 citations in OpenAlex.
- Commissioning and Validation of a Synchrocyclotron - Based Ultra-High-Dose-Rate Beamline for FLASH.International journal of particle therapy · 2026Article
- Lighting up FLASH and beyond: TLD response across four orders of magnitude in proton dose rate.Medical physics · 2026Article
- A high-precision image-guided platform for studying spinal cord toxicity under ultra-high dose rate electron irradiation.Physics in medicine and biology · 2026Article
- FLASH radiotherapy as an emerging paradigm in radioimmunotherapy: biological rationale, preclinical evidence, and translational roadmap.Frontiers in immunology · 2026Review
- FLASH radiotherapy and immunotherapy synergy: mechanisms, strategies, and clinical translation prospects.Frontiers in immunology · 2026Review
- Systematic analysis of biological endpoint variability and implications for quantitative modeling of the FLASH sparing effect.Physics and imaging in radiation oncology · 2026Review
- Emulating Clinical Workflow of Scintillator Array Dosimetry for FLASH Pencil-Beam Scanning Proton Therapy.International journal of radiation oncology, biology, physics · 2025Article
- Experimental design and control methods for dose rate optimization in a synchrotron-based proton therapy beamline.Precision radiation oncology · 2025Article
- Feasibility of prototype diamond detectors for pulsed UHDR PBS small-field proton dosimetry for proton FLASH experiments.Physics in medicine and biology · 2025Article
- Quality assurance and reporting for FLASH clinical trials: The experience of the FEATHER trial.Medical physics · 2025Article
- Characterization of commercial detectors for absolute proton UHDR dosimetry on a compact clinical proton synchrocyclotron.Medical physics · 2025Article
- Design and characterization of a novel scintillator array for UHDR PBS proton therapy surface dosimetry.Medical physics · 2025Article
- Imaging system for real-time, full-field pulse-by-pulse surface dosimetry of UHDR electron beams.Medical physics · 2025Article
- Verification of dose and dose rate for quality assurance of spread-out-Bragg-peak proton FLASH radiotherapy using machine log files.Medical physics · 2025Article
- First Retrospective QA of FAST-01 Clinical Treatment Fields Using High-Speed Quantitative Scintillation Imaging.International journal of radiation oncology, biology, physics · 2025Article
- Effect of FLASH dose-rate and oxygen concentration in the production of HPhysics in medicine and biology · 2025Article
- Mimicking large spot-scanning radiation fields for proton FLASH preclinical studies with a robotic motion platform.Precision radiation oncology · 2024Article
- Advancing the Collaboration Between Imaging and Radiation Oncology.Seminars in radiation oncology · 2024Review
- Quantitative, real-time scintillation imaging for experimental comparison of different dose and dose rate estimations in UHDR proton pencil beams.Medical physics · 2024Article
- First Monte Carlo beam model for ultra-high dose rate radiotherapy with a compact electron LINAC.Medical physics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
While FLASH radiation therapy is inspiring enthusiasm to transform the field, it is neither new nor well understood with respect to the radiobiological mechanisms. As FLASH clinical trials are designed, it will be important to ensure we can deliver dose consistently and safely to every patient. Much like hyperthermia and proton therapy, FLASH is a promising new technology that will be complex to implement in the clinic and similarly will require customized credentialing for multi-institutional clinical trials. There is no doubt that FLASH seems promising, but many technologies that we take for granted in conventional radiation oncology, such as rigorous dosimetry, 3D treatment planning, volumetric image guidance, or motion management, may play a major role in defining how to use, or whether to use, FLASH radiotherapy. Given the extended time frame for patients to experience late effects, we recommend moving deliberately but cautiously forward toward clinical trials. In this paper, we review the state of quality assurance and safety systems in FLASH, identify critical pre-clinical data points that need to be defined, and suggest how lessons learned from previous technological advancements will help us close the gaps and build a successful path to evidence-driven FLASH implementation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.