Evidence map›Paper›PMID 35366338›Full record

ArticleEpilepsia2022

Susceptibility to epilepsy after traumatic brain injury is associated with preexistent gut microbiome profile.

Jesus-Servando Medel-Matus, Venu Lagishetty, Cesar Santana-Gomez, Don Shin, Wenzhu Mowrey, Richard J Staba, Aristea S Galanopoulou, Raman Sankar, Jonathan P Jacobs, Andrey M Mazarati

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 27 citations in OpenAlex.

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  6. Theranostics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jesus-Servando Medel-MatusDepartment of Pediatrics, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0003-1103-468X
Venu LagishettyDepartment of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.
Cesar Santana-GomezDepartment of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0001-9163-5615
Don ShinDepartment of Pediatrics, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.
Wenzhu MowreyDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Richard J StabaDepartment of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.
Aristea S GalanopoulouSaul Korey Department of Neurology, Dominick Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0002-0472-2903
Raman SankarDepartment of Pediatrics, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.
Jonathan P JacobsDepartment of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.
Andrey M MazaratiDepartment of Pediatrics, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0001-9693-5297
University of California, Los Angeles · USAlbert Einstein College of Medicine · US

Funding

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Public Engagement CoreU54NS100064 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ENGEL, JEROME NONE, GALANOPOULOU, ARISTEA S · 2017 to 2021
$21.7M
Modulation of the Intestinal Microbiome in Obesity by a High Protein DietIK2CX001717 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI JACOBS, JONATHAN PATRICK · 2018 to 2023
–
CSRD VA IK2 CX001717NINDS NIH HHS U54 NS100064
6 · The paper itself

Abstract

objectiveWe examined whether posttraumatic epilepsy (PTE) is associated with measurable perturbations in gut microbiome.

methodsAdult Sprague Dawley rats were subjected to lateral fluid percussion injury (LFPI). PTE was examined 7 months after LFPI, during 4-week continuous video-electroencephalographic monitoring. 16S ribosomal RNA gene sequencing was performed in fecal samples collected before LFPI/sham-LFPI and 1 week, 1 month, and 7 months thereafter. Longitudinal analyses of alpha diversity, beta diversity, and differential microbial abundance were performed. Short-chain fatty acids (SCFAs) were measured in fecal samples collected before LFPI by liquid chromatography with tandem mass spectrometry.

resultsAlpha diversity changed over time in both LFPI and sham-LFPI subjects; no association was observed between alpha diversity and LFPI, the severity of post-LFPI neuromotor impairments, and PTE. LFPI produced significant changes in beta diversity and selective changes in microbial abundances associated with the severity of neuromotor impairments. No association between LFPI-dependent microbial perturbations and PTE was detected. PTE was associated with beta diversity irrespective of timepoint vis-à-vis LFPI, including at baseline. Preexistent fecal microbial abundances of four amplicon sequence variants belonging to the Lachnospiraceae family (three enriched and one depleted) predicted the risk of PTE, with area under the curve (AUC) of .73. Global SCFA content was associated with the increased risk of PTE, with AUC of .722, and with 2-methylbutyric (depleted), valeric (depleted), isobutyric (enriched), and isovaleric (enriched) acids being the most important factors (AUC = .717). When the analyses of baseline microbial and SCFA compositions were combined, AUC to predict PTE increased to .78. SIGNIFICANCE: Whereas LFPI produces no perturbations in the gut microbiome that are associated with PTE, the risk of PTE can be stratified based on preexistent microbial abundances and SCFA content.

Indexed as

Brain Injuries, TraumaticEpilepsyEpilepsy, Post-TraumaticGastrointestinal MicrobiomeAnimalsFatty Acids, VolatileHumansRatsRats, Sprague-DawleyFatty Acids, Volatilefluid percussion injurymicrobiotaposttraumatic epilepsyrandom forest classifiershort-chain fatty acids

Identifiers

PMID35366338
PMCPMC9656503
OpenAlexW4224016889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.