Evidence map›Paper›PMID 35366291›Full record

ArticlePathophysiology : the official journal of the International Society for Pathophysiology2022

Polymorphism in Adiponectin and Adiponectin Receptor Genes in Diabetes Mellitus Pathogenesis.

Iuliana Shramko, Elizaveta Ageeva, Eugene Krutikov, Konstantin Maliy, Irina Repinskaya, Iryna Fomochkina, Anatolii Kubishkin, Anna Gurtovaya, Cyrill Tarimov, Suman Shekhar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathophysiology : the official journal of the International Society for Pathophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Effect of Genetic Variations in theDiabetes, metabolic syndrome and obesity : targets and therapy · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Iuliana ShramkoDepartment of General and Clinical Pathophysiology, S. I. Georgievsky Medical Academy of the Federal State Autonomous Educational Institution of Higher Education, V. I. Vernadsky Crimean Federal University, 295000 Simferopol, Russia.ORCID 0000-0003-4946-7317
Elizaveta AgeevaDepartment of Medical Biology, S. I. Georgievsky Medical Academy of the Federal State Autonomous Educational Institution of Higher Education, V. I. Vernadsky Crimean Federal University, 295000 Simferopol, Russia.
Eugene KrutikovDepartment of Propaedeutics of Internal Medicine, S. I. Georgievsky Medical Academy of the Federal State Autonomous Educational Institution of Higher Education, V. I. Vernadsky Crimean Federal University, 295000 Simferopol, Russia.
Konstantin MaliyDepartment of Biochemistry, S. I. Georgievsky Medical Academy of the Federal State Autonomous Educational Institution of Higher Education, V. I. Vernadsky Crimean Federal University, 295000 Simferopol, Russia.
Irina RepinskayaDepartment of Internal Medicine, S. I. Georgievsky Medical Academy of the Federal State Autonomous Educational Institution of Higher Education, V. I. Vernadsky Crimean Federal University, 295000 Simferopol, Russia.
Iryna FomochkinaDepartment of Basic and Clinical Pharmacology, S. I. Georgievsky Medical Academy of the Federal State Autonomous Educational Institution of Higher Education, V. I. Vernadsky Crimean Federal University; 295000 Simferopol, Russia.
Anatolii KubishkinDepartment of General and Clinical Pathophysiology, S. I. Georgievsky Medical Academy of the Federal State Autonomous Educational Institution of Higher Education, V. I. Vernadsky Crimean Federal University, 295000 Simferopol, Russia.
Anna GurtovayaDepartment of Medical Biology, S. I. Georgievsky Medical Academy of the Federal State Autonomous Educational Institution of Higher Education, V. I. Vernadsky Crimean Federal University, 295000 Simferopol, Russia.
Cyrill TarimovDepartment of General and Clinical Pathophysiology, S. I. Georgievsky Medical Academy of the Federal State Autonomous Educational Institution of Higher Education, V. I. Vernadsky Crimean Federal University, 295000 Simferopol, Russia.
Suman ShekharDepartment of Medical Biology, S. I. Georgievsky Medical Academy of the Federal State Autonomous Educational Institution of Higher Education, V. I. Vernadsky Crimean Federal University, 295000 Simferopol, Russia.
Research Institute of Agriculture of Crimea · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role played by hereditary factors in the development of diabetes mellitus type 2 (DM2) has not yet been fully established. Therefore, the purpose of our study was to investigate the prevalence of adiponectin and polymorphism in its gene receptors in connection with the primary symptoms of DM2 pathogenesis. Genomic DNA was isolated from the whole blood of 94 patients with an established diagnosis of DM2 using the phenol-chloroform method. Gene polymorphisms were determined using real-time polymerase chain reaction (PCR). The most common polymorphic variants in patients with DM2 were the genotypes AA (rs11061971) and GG (rs16928751) on the ADIPOR2 gene. A strong correlation was found between the rs16928751 polymorphism on the ADIPOR2 gene and increased body mass index (BMI). TG (rs2275737) ADIPOR1 gene genotype carriers were found to have the highest levels of glycosylated hemoglobin (HbA1), whereas TT (rs2275738) caused stable hyperglycemia. In addition, the rs16928751 ADIPOR2 gene polymorphism showed an association with the development of key mechanisms of DM2 in the Russian population, although a number of genomic searches failed to show any association of this gene with DM2. Unique gene variants associated with the risk of developing DM2 in the Crimean population were established.

Indexed as

adiponectinadiponectin receptorsdiabetes mellitusgene polymorphism

Identifiers

PMID35366291
PMCPMC8956057
OpenAlexW4214707505

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.