Evidence map›Paper›PMID 35366258›Full record

ArticlePathophysiology : the official journal of the International Society for Pathophysiology2021

Critically Ill COVID-19 Patients Exhibit Anti-SARS-CoV-2 Serological Responses.

Douglas D Fraser, Gediminas Cepinskas, Marat Slessarev, Claudio M Martin, Mark Daley, Maitray A Patel, Michael R Miller, Eric K Patterson, David B O'Gorman, Sean E Gill and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathophysiology : the official journal of the International Society for Pathophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Douglas D FraserLawson Health Research Institute, London, ON N6C 2R5, Canada.ORCID 0000-0002-5635-3791
Gediminas CepinskasLawson Health Research Institute, London, ON N6C 2R5, Canada.
Marat SlessarevLawson Health Research Institute, London, ON N6C 2R5, Canada.ORCID 0000-0003-1181-0706
Claudio M MartinLawson Health Research Institute, London, ON N6C 2R5, Canada.
Mark DaleyLawson Health Research Institute, London, ON N6C 2R5, Canada.ORCID 0000-0002-6939-9772
Maitray A PatelDepartment of Computer Science, Western University, London, ON N6A 3K7, Canada.
Michael R MillerLawson Health Research Institute, London, ON N6C 2R5, Canada.
Eric K PattersonLawson Health Research Institute, London, ON N6C 2R5, Canada.ORCID 0000-0003-3697-3042
David B O'GormanLawson Health Research Institute, London, ON N6C 2R5, Canada.
Sean E GillLawson Health Research Institute, London, ON N6C 2R5, Canada.
Ian HigginsDiagnostics Biochem Canada, London, ON N6M 1A1, Canada.
Julius P P JohnDiagnostics Biochem Canada, London, ON N6M 1A1, Canada.
Christopher MeloDiagnostics Biochem Canada, London, ON N6M 1A1, Canada.
Lylia NiniDiagnostics Biochem Canada, London, ON N6M 1A1, Canada.
Xiaoqin WangDiagnostics Biochem Canada, London, ON N6M 1A1, Canada.
Johannes ZeidlerDiagnostics Biochem Canada, London, ON N6M 1A1, Canada.
Jorge A Cruz-AguadoDiagnostics Biochem Canada, London, ON N6M 1A1, Canada.

Funding

Academic Medical Organization of Southwestern Ontario DDF2020Lawson Health Research Institute IRF
6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a global health care emergency. Anti-SARS-CoV-2 serological profiling of critically ill COVID-19 patients was performed to determine their humoral response. Blood was collected from critically ill ICU patients, either COVID-19 positive (+) or COVID-19 negative (-), to measure anti-SARS-CoV-2 immunoglobulins: IgM; IgA; IgG; and Total Ig (combined IgM/IgA/IgG). Cohorts were similar, with the exception that COVID-19+ patients had a greater body mass indexes, developed bilateral pneumonias more frequently and suffered increased hypoxia when compared to COVID-19- patients (

Indexed as

COVID-19humoral responseimmunoglobulinsintensive care unitoutcomeserology

Identifiers

PMID35366258
PMCPMC8830473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.