ArticleApplied biochemistry and biotechnology2022
Antifungal Activity of Endophytic Aspergillus terreus Extract Against Some Fungi Causing Mucormycosis: Ultrastructural Study.
Article in Applied biochemistry and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed.
- Morpho-molecular approach reveals a myco-endophyte, Aspergillus novoparasiticus CBS126849 (MTCC-13997) from the roots of Capparis decidua with therapeutic and enzymatic potential.Archives of microbiology · 2026Article
- Untapped microbial factories for next-generation therapeutics: Endophytic fungi of medicinal plants.Microbial cell factories · 2026Review
- Green mycosynthesis of ZnO nanoparticles enhances antifungal defense against Fusarium equiseti through metabolic and gene expression modulation.Discover nano · 2026Article
- Characterization and biological activities of endophytic bacteria from Vernonia anthelmintica flowers.Folia microbiologica · 2026Article
- Synthesis of Chitosan based nanoemulsions and their characterization and antifungal activity toward fungi causing mucormycosis.Scientific reports · 2025Article
- Diversity and bioprospecting activities of endophytic Fungi associated with different Egyptian medicinal plants.Scientific reports · 2025Article
- Article
- The Role of Oxidative Stress in the Antifungal Activity of Two Mollusk Fractions on Resistant Fungal Strains.International journal of molecular sciences · 2025Article
- An eco-friendly and cost-effective approach for the synthesis of a novel GA@CuO-ZnO nanocomposite: characterization, antimicrobial and anticancer activities.RSC advances · 2025Article
- Isolation of the Endophytic FungusPlants (Basel, Switzerland) · 2024Article
- Antibacterial and anticancer potential of bioactive compounds and secondary metabolites of endophytic fungi isolated fromFrontiers in microbiology · 2024Article
- Unveiling theFrontiers in microbiology · 2024Article
- Neem Essential Oil as an Antifungal Agent againstInternational journal of microbiology · 2024Article
- Antimicrobial, Antibiofilm, and Anticancer Activities ofMolecules (Basel, Switzerland) · 2023Article
- Unveiling anticancer, antimicrobial, and antioxidant activities of novel synthesized bimetallic boron oxide-zinc oxide nanoparticles.RSC advances · 2023Article
- Efficient Role of EndophyticMicroorganisms · 2023Article
- Endophytes in Agriculture: Potential to Improve Yields and Tolerances of Agricultural Crops.Microorganisms · 2023Review
- Improvement in the Phytochemical Content and Biological Properties ofPlants (Basel, Switzerland) · 2023Article
- Potential Antimicrobial and Antibiofilm Properties of Copper Oxide Nanoparticles: Time-Kill Kinetic Essay and Ultrastructure of Pathogenic Bacterial Cells.Applied biochemistry and biotechnology · 2023Article
- Antifungal activity of volatile and non-volatile metabolites of endophytes ofFrontiers in plant science · 2023Article
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5 authors.
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Abstract
Endophytes fungi are applied as favorable safe antifungal agents as well as natural bioactive compounds reservoir. In the current study, the inhibitory effect of endophytic fungus was explained by direct antifungal activity against fungi causing mucormycosis, ultrastructural, and determination of active compounds in fungal extract. Endophytic Aspergillus terreus was isolated from healthy Moringa oleifera leaves and identified morphologically and genetically, and was recorded in gene bank with accession number MW444551.1. Phytochemical analysis and gas chromatography-mass spectroscopy (GC-MS) of ethyl acetate crude extract (EACE) of A. terreus were performed. GC-MS results of EACE of A. terreus revealed that fungal extract contains 16 major bioactive compounds with extensive pharmaceutical activities. Furthermore, EACE of A. terreus revealed a promising antifungal activity against fungi causing mucormycosis as Rhizopus oryzae, Mucor racemosus, and Syncephalastrum racemosum, where inhibition zones of EACE (10 mg/ml) were 20, 37, and 18 mm, respectively. Minimum inhibitory concentration (MIC) of EACE was 0.3125 toward M. racemosus, while 1.25 and 2.5 mg/ml against R. oryzae and S. racemosum, respectively. In the same context, treated R. oryzae, M. racemosus, and S. racemosum with EACE of A. terreus revealed elevation of membrane lipid peroxidation which approves membrane leakage. Furthermore, ultrastructure changes were observed which established alteration in both sporangium and hyphal structures; cell membrane and cytoplasm leakage. In conclusion, endophytic A. terreus has an outstanding antifungal activity against fungi causing mucormycosis.
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