Evidence map›Paper›PMID 35366073›Full record

ArticlePediatric radiology2022

Free-breathing radial magnetic resonance elastography of the liver in children at 3 T: a pilot study.

Sevgi Gokce Kafali, Tess Armstrong, Shu-Fu Shih, Grace J Kim, Joseph L Holtrop, Robert S Venick, Shahnaz Ghahremani, Bradley D Bolster, Claudia M Hillenbrand, Kara L Calkins and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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  5. MASLD: What We Have Learned and Where We Need to Go-A Call to Action.Radiographics : a review publication of the Radiological Society of North America, Inc · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Sevgi Gokce KafaliDepartment of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 300 UCLA Medical Plaza, Suite B119, Los Angeles, CA, 90095, USA.ORCID 0000-0001-5941-5399
Tess ArmstrongDepartment of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 300 UCLA Medical Plaza, Suite B119, Los Angeles, CA, 90095, USA.
Shu-Fu ShihDepartment of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 300 UCLA Medical Plaza, Suite B119, Los Angeles, CA, 90095, USA.
Grace J KimDepartment of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 300 UCLA Medical Plaza, Suite B119, Los Angeles, CA, 90095, USA.
Joseph L HoltropDepartment of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, USA.
Robert S VenickDepartment of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Shahnaz GhahremaniDepartment of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 300 UCLA Medical Plaza, Suite B119, Los Angeles, CA, 90095, USA.
Bradley D BolsterSiemens Medical Solutions, Inc., Salt Lake City, UT, USA.
Claudia M HillenbrandDepartment of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, USA.
Kara L CalkinsDepartment of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Holden H WuDepartment of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, 300 UCLA Medical Plaza, Suite B119, Los Angeles, CA, 90095, USA. HoldenWu@mednet.ucla.edu.ORCID 0000-0002-2585-5916
University of California, Los Angeles · USSt. Jude Children's Research Hospital · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Quantifying Body Composition and Liver Disease in Children using Free-Breathing MRI and MRER01DK124417 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CALKINS, KARA LYNNE, WU, HOLDEN H · 2020 to 2023
$2.3M
NCATS NIH HHS UL1 TR001881NIDDK NIH HHS R01 DK124417
6 · The paper itself

Abstract

backgroundMagnetic resonance (MR) elastography of the liver measures hepatic stiffness, which correlates with the histopathological staging of liver fibrosis. Conventional Cartesian gradient-echo (GRE) MR elastography requires breath-holding, which is challenging for children. Non-Cartesian radial free-breathing MR elastography is a potential solution to this problem.

objectiveTo investigate radial free-breathing MR elastography for measuring hepatic stiffness in children. MATERIALS AND

methodsIn this prospective pilot study, 14 healthy children and 9 children with liver disease were scanned at 3 T using 2-D Cartesian GRE breath-hold MR elastography (22 s/slice) and 2-D radial GRE free-breathing MR elastography (163 s/slice). Each sequence was acquired twice. Agreement in the stiffness measurements was evaluated using Lin's concordance correlation coefficient (CCC) and within-subject mean difference. The repeatability was assessed using the within-subject coefficient of variation and intraclass correlation coefficient (ICC).

resultsFourteen healthy children and seven children with liver disease completed the study. Median (±interquartile range) normalized measurable liver areas were 62.6% (±26.4%) and 44.1% (±39.6%) for scan 1, and 60.3% (±21.8%) and 43.9% (±44.2%) for scan 2, for Cartesian and radial techniques, respectively. Hepatic stiffness from the Cartesian and radial techniques had close agreement with CCC of 0.89 and 0.94, and mean difference of 0.03 kPa and -0.01 kPa, for scans 1 and 2. Cartesian and radial techniques achieved similar repeatability with within-subject coefficient of variation=1.9% and 3.4%, and ICC=0.93 and 0.92, respectively.

conclusionIn this pilot study, radial free-breathing MR elastography was repeatable and in agreement with Cartesian breath-hold MR elastography in children.

Indexed as

Elasticity Imaging TechniquesLiver DiseasesChildHumansLiverMagnetic Resonance ImagingPilot ProjectsProspective StudiesReproducibility of ResultsChildrenFibrosisFree-breathingLiverMagnetic resonance elastographyMagnetic resonance imagingRadial imagingStiffness

Identifiers

PMID35366073
PMCPMC9192470
OpenAlexW4226182776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.