Evidence map›Paper›PMID 35366056›Full record

ArticleJournal of cellular and molecular medicine2022

N-α-Acetyltransferase 10 inhibits invasion and metastasis of oral squamous cell carcinoma via regulating Pirh2-p53 signalling pathway.

Fazhan Wang, Jun Zheng, Jie Yang, Ting Luo, Jiang Xu, Yongyong Yang, Yongqing Gu, Yan Zeng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Conformational plasticity links structural instability of NAA10Computational and structural biotechnology journal · 2024
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Fazhan WangPrecision Clinical Laboratory, Central People's Hospital of Zhanjiang, Guangdong Medical University Zhanjiang Central Hospital, Zhanjiang, China.
Jun ZhengPrecision Clinical Laboratory, Central People's Hospital of Zhanjiang, Guangdong Medical University Zhanjiang Central Hospital, Zhanjiang, China.
Jie YangKey Laboratory of Xinjiang Endemic and Ethnic Disease, School of Medicine, Shihezi University, Shihezi, China.
Ting LuoKey Laboratory of Xinjiang Endemic and Ethnic Disease, School of Medicine, Shihezi University, Shihezi, China.
Jiang XuKey Laboratory of Xinjiang Endemic and Ethnic Disease, School of Medicine, Shihezi University, Shihezi, China.
Yongyong YangDepartment of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Yongqing GuBeijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, China.
Yan ZengPrecision Clinical Laboratory, Central People's Hospital of Zhanjiang, Guangdong Medical University Zhanjiang Central Hospital, Zhanjiang, China.ORCID 0000-0002-9823-1266
Shihezi University · CNBeijing Radiation Center · CNNorthwestern University · US

Funding

National Natural Science Foundation of China 81560473Shihezi University CGZH202001Shihezi University GJHZ201901Xinjiang Production and Construction Corps Science and Technology 2018CB002Xinjiang Production and Construction Corps Science and Technology 2021BC004
6 · The paper itself

Abstract

N-α-Acetyltransferase 10 (NAA10) was reported to be involved in tumour invasion and metastasis in several of tumours. However, the role and mechanism of NAA10-mediated invasion and metastasis in oral squamous cell carcinoma (OSCC) remains undetermined. Herein, our study showed that NAA10 inhibits cell migration and invasion in vitro and attenuates the xenograft tumorigenesis in nude mice. Mechanistically, we demonstrated that there is a physical interaction between NAA10 and RelA/p65 in OSCC cells, thereby preventing RelA/p65-mediated transcriptional activation of Pirh2. Consequently, inhibition of Pirh2 increased p53 level and suppressed the expression of p53 downstream targets, matrix metalloprotein-2 (MMP-2) and MMP-9. Therefore, NAA10 may function as a tumour metastasis suppressor in the progression of OSCC by targeting Pirh2-p53 axis and might be a prognostic marker as well as a therapeutic target for OSCC.

Indexed as

Mouth NeoplasmsN-Terminal Acetyltransferase AN-Terminal Acetyltransferase ESquamous Cell Carcinoma of Head and NeckAnimalsCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansMiceMice, NudeTumor Suppressor Protein p53Ubiquitin-Protein LigasesNAA10 protein, humanN-Terminal Acetyltransferase AN-Terminal Acetyltransferase ERCHY1 protein, humanTumor Suppressor Protein p53Ubiquitin-Protein LigasesinvasionmetastasisNAA10OSCCPirh2-p53

Identifiers

PMID35366056
PMCPMC9097830
OpenAlexW4224022063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.