Evidence map›Paper›PMID 35365950›Full record

ArticleLiver international : official journal of the International Association for the Study of the Liver2022

Frequency of the PNPLA3 rs738409 polymorphism and other genetic loci for liver disease in a Guatemalan adult population.

Mariana Lazo, Jiaqi Xie, Christian S Alvarez, Dominick Parisi, Stephanie Yang, Alvaro Rivera-Andrade, Maria F Kroker-Lobos, John D Groopman, Eliseo Guallar, Manuel Ramirez-Zea and 2 more

Open access · greenAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Liver international : official journal of the International Association for the Study of the Liver, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Global Epidemiological Impact of PNPLA3 I148M on Liver Disease.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Mariana LazoDepartment of Community Health and Prevention, Drexel Dornsife School of Public Health, Philadelphia, Pennsylvania, USA.
Jiaqi XieDepartment of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Christian S AlvarezDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.ORCID 0000-0002-5338-0444
Dominick ParisiInformation Management Services, Colesville, Maryland, USA.
Stephanie YangDepartment of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Alvaro Rivera-AndradeINCAP Research Center for the Prevention of Chronic Diseases, Institute of Nutrition of Central America and Panama, Guatemala City, Guatemala.
Maria F Kroker-LobosINCAP Research Center for the Prevention of Chronic Diseases, Institute of Nutrition of Central America and Panama, Guatemala City, Guatemala.
John D GroopmanJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Eliseo GuallarJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Manuel Ramirez-ZeaINCAP Research Center for the Prevention of Chronic Diseases, Institute of Nutrition of Central America and Panama, Guatemala City, Guatemala.
Dan E ArkingDepartment of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Katherine A McGlynnDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.ORCID 0000-0003-2329-9933
Johns Hopkins University · USInstitute of Nutrition of Central America and Panama · GTNational Cancer Institute · USInformation Management Services · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Studies of Rare CancersZIACP010158 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MCGLYNN, KATHERINE · 2009 to 2025
$19.1M
NCATS NIH HHS UL1 TR003098NCI NIH HHS P30 CA006973NCRR NIH HHS UL1 RR025005
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AcyltransferasesLiver DiseasesNon-alcoholic Fatty Liver DiseasePhospholipases A2, Calcium-IndependentAdultGenetic LociGenetic Predisposition to DiseaseGenotypeHumansLiverPolymorphism, GeneticPolymorphism, Single NucleotideAcyltransferasesPhospholipases A2, Calcium-IndependentPNPLA3 protein, humangeneticsGuatemalaLatinosNAFLDPNPLA3

Identifiers

PMID35365950
PMCPMC9241623
OpenAlexW4223479262

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.