ArticleMolecular psychiatry2022
Transcriptome-wide association study for postpartum depression implicates altered B-cell activation and insulin resistance.
Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Immune-metabolic mediation of depression risk: Causal evidence from antibody and metabolite GWAS.Translational psychiatry · 2026Article
- A large-scale DNA methylation study of alcohol use identified robust associations and cell-type specific insights.Molecular psychiatry · 2026Article
- Causal Relationship between Immune Cells and Postpartum Depression: A Bidirectional Two-Sample Mendelian Randomization Study.Iranian journal of public health · 2025Article
- Differentially expressed transcripts associated with depressive symptoms during pregnancy and postpartum.Molecular psychiatry · 2025Article
- Druggable Targets for Postpartum Depression: A Mendelian Randomization and Colocalization Study.Cellular and molecular neurobiology · 2025Article
- Blood transcriptomic signatures associated with depression, or the risk for depression, in pregnant women from the Psychiatry Research And Motherhood - Depression (PRAM-D) study.Translational psychiatry · 2025Article
- Association of estrogen receptor single nucleotide polymorphisms and perinatal depression.PloS one · 2025Article
- Gestational diabetes mellitus and peripartum depression: a longitudinal study of a bidirectional relationship.BMC pregnancy and childbirth · 2024Article
- Investigating neonatal health risk variables through cell-type specific methylome-wide association studies.Clinical epigenetics · 2024Article
- Revealing genetic causality between blood-based biomarkers and major depression in east Asian ancestry.Frontiers in psychiatry · 2024Article
- Social stress induces autoimmune responses against the brain.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A dynamic perspective on depressive symptoms during the first year postpartum.Journal of psychopathology and clinical science · 2023Article
- Biomarkers of Postpartum Depression: A Narrative Review.Journal of clinical medicine · 2023Review
- The role of gut microbiota in the pathogenesis and treatment of postpartum depression.Annals of general psychiatry · 2023Review
- Challenges and Opportunities for Data Science in Women's Health.Annual review of biomedical data science · 2023Review
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Authors and funding
7 authors.
Funding
Abstract
Postpartum depression (PPD) affects 1 in 7 women and has negative mental health consequences for both mother and child. However, the precise biological mechanisms behind the disorder are unknown. Therefore, we performed the largest transcriptome-wide association study (TWAS) for PPD (482 cases, 859 controls) to date using RNA-sequencing in whole blood and deconvoluted cell types. No transcriptional changes were observed in whole blood. B-cells showed a majority of transcriptome-wide significant results (891 transcripts representing 789 genes) with pathway analyses implicating altered B-cell activation and insulin resistance. Integration of other data types revealed cell type-specific DNA methylation loci and disease-associated eQTLs (deQTLs), but not hormones/neuropeptides (estradiol, progesterone, oxytocin, BDNF), serve as regulators for part of the transcriptional differences between cases and controls. Further, deQTLs were enriched for several brain region-specific eQTLs, but no overlap with MDD risk loci was observed. Altogether, our results constitute a convergence of evidence for pathways most affected in PPD with data across different biological mechanisms.
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