ArticleScientific reports2022
A multi-omics approach to elucidate the mechanisms of action of a dietary muramidase administered to broiler chickens.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Optimizing Broiler Performance and Intestinal Morphology and Increasing Nutritional Availability via Microbial Muramidase Supplementation.Animals : an open access journal from MDPI · 2026Article
- Modulation of the nutritional, metabolomic and microRNA profile of colostrum and piglet performance via a high-energy, high-lysine transition diet in sows.Journal of animal science and biotechnology · 2026Article
- Dietary muramidase leads to the downregulation of peptidoglycan biosynthesis and to caecal microbial modulation in laying hens.Animal microbiome · 2026Article
- Intrauterine growth restriction, defined by an elevated brain-to-liver weight ratio, affects faecal microbiota composition and, to a lesser extent, plasma metabolome profile at different ages in pigs.Animal microbiome · 2025Article
- ASAS-NANP symposium: mathematical modeling in animal nutrition: overview of poultry nutrition modeling.Journal of animal science · 2025Review
- Metabolomic analysis of synovial fluid from healthy and pathological equine joints and tendon sheaths using high-resolutionFrontiers in veterinary science · 2025Article
- Productive and metabolomic consequences of arginine supplementation in sows during different gestation periods in two different seasons.Journal of animal science and biotechnology · 2024Article
- Comparative study ofScientific reports · 2024Article
- Effects of Dietary Microbial Muramidase on the Growth, Liver Histoarchitecture, Antioxidant Status, and Immunoexpression of Pro-Inflammatory Cytokines in Broiler Chickens.Animals : an open access journal from MDPI · 2023Article
- Synovial Fluid Metabolome Can Differentiate between Healthy Joints and Joints Affected by Osteoarthritis in Horses.Metabolites · 2023Article
- New Insights into the Effects of Microbial Muramidase Addition in the Diets of Broiler Chickens.Animals : an open access journal from MDPI · 2023Article
- Feeding broiler chickens with arginine above recommended levels: effects on growth performance, metabolism, and intestinal microbiota.Journal of animal science and biotechnology · 2023Article
- Insight into the long-term impact of birth weight on intestinal development, microbial settlement, and the metabolism of weaned piglets.Journal of animal science · 2023Article
- Effects of Dietary Coated Lysozyme on the Growth Performance, Antioxidant Activity, Immunity and Gut Health of Weaned Piglets.Antibiotics (Basel, Switzerland) · 2022Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel dietary muramidase has been shown to have positive effects on broiler chickens. However, very little is known about its mechanisms of action. The present multi-omics investigation sought to address this knowledge gap. A total of 2,340 day-old male broilers were assigned to 3 groups (12 replicates each) fed, from 0 to 42 d, a basal diet (control group-CON) or the basal diet supplemented with muramidase at 25,000 (low-dose group-MUL) or 45,000 LSU(F)/kg feed (high-dose group-MUH). MUH significantly outperformed CON in terms of cumulative feed intake (4,798 vs 4,705 g), body weight (2,906 vs 2,775 g), and feed conversion ratio (1.686 vs 1.729), while MUL exhibited intermediate performance. At caecal level, MUH showed the lowest alpha diversity, a significantly different beta diversity, a reduction in Firmicutes, and a rise in Bacteroidetes, especially compared with MUL. MUH also exhibited a considerable decrease in Clostridiaceae and an overrepresentation of Bacteroidaceae and Lactobacillaceae. At blood level, MUH had lower hypoxanthine-probably due to its drop at caecal level-histidine, and uracil, while greater pyruvate, 2-oxoglutarate, and glucose. This study sheds light on the mode of action of this muramidase and lays the groundwork for future investigations on its effects on the intestinal ecosystem and systemic metabolism of broiler chickens.
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