ArticleCommunications biology2022
Growth promotion and antibiotic induced metabolic shifts in the chicken gut microbiome.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Behavioral responses of pigs to dietary alternatives to antibiotic growth promoters: a systematic review.Veterinary research communications · 2026Pooled it
- Chick neonatal environment: the presence of a hen, not hatching system, promotes cecal microbiota development and induces limited long-term effects on immunity and redox balance.Poultry science · 2026Article
- Hastening meat production: a review of growth promoters for traditional and cultured meat production.Journal of animal science and technology · 2026Review
- Lactobacillus-vectored nanobodies improve broiler productivity under sub-clinical necrotic enteritis with associated microbiome and transcriptome changes.NPJ biofilms and microbiomes · 2026Article
- Long-reads metagenomics reveals the effects of dulse supplementation on the poultry caecal bacteriome and its associated genetic repertoire.Frontiers in microbiology · 2026Article
- Effects of flammulina velutipes stipe wastes on egg performance, cecum microbiota, intestinal barrier and serum immune response of laying hens.BMC veterinary research · 2025Article
- Prospects for antibiotic-free poultry production in South Africa: An analysis of the enablers and stumbling blocks.One health (Amsterdam, Netherlands) · 2025Review
- Integrating serotyping, MLST, and phenotypic data: decoding the evolutionary drivers ofApplied and environmental microbiology · 2025Article
- Xenobiotics and Broiler Microbiota: Molecular Insights into Bacterial Antimicrobial Resistance and Food Safety Implications for Human Health.Journal of xenobiotics · 2025Review
- Enhancing Holstein steers growth performance: oregano essential oil's impact on rumen development, functionality and microorganism.Animal microbiome · 2025Article
- Alternatives to antibiotics for sustainable livestock production in the context of the One Health approach: tackling a common foe.Frontiers in veterinary science · 2025Review
- The role of gut microbiota-derived metabolites in modulating poultry immunometabolism.Frontiers in physiology · 2025Review
- Prophage induction drives soybean rhizobacterial community differentiation and nutrient cycling benefiting root development.ISME communications · 2025Article
- Gut health modulation through phytogenics in poultry: mechanisms, benefits, and applications.Frontiers in veterinary science · 2025Review
- Development and Evaluation of Non-Antibiotic Growth Promoters for Food Animals.Veterinary sciences · 2024Article
- Effects of Guanidine Acetic Acid on the Growth and Slaughter Performance, Meat Quality, Antioxidant Capacity, and Cecal Microbiota of Broiler Chickens.Veterinary sciences · 2024Article
- Evaluation of the growth performance, meat quality, and gut microbiota of broilers fed diets containing walnut green husk extract.Poultry science · 2024Article
- Effect of Early Ciprofloxacin Administration on Growth Performance, Meat Quality, Food Safety, and Metabolomic Profiles in Xueshan Chickens.Animals : an open access journal from MDPI · 2024Article
- Intestinal Microbiome Profiles in Broiler Chickens Raised with Different Probiotic Strains.Microorganisms · 2024Article
- Modulation of chicken gut microbiota for enhanced productivity and health: A review.Veterinary world · 2024Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial growth promoters (AGP) have played a decisive role in animal agriculture for over half a century. Despite mounting concerns about antimicrobial resistance and demand for antibiotic alternatives, a thorough understanding of how these compounds drive performance is missing. Here we investigate the functional footprint of microbial communities in the cecum of chickens fed four distinct AGP. We find relatively few taxa, metabolic or antimicrobial resistance genes similarly altered across treatments, with those changes often driven by the abundances of core microbiome members. Constraints-based modeling of 25 core bacterial genera associated increased performance with fewer metabolite demands for microbial growth, pointing to altered nitrogen utilization as a potential mechanism of narasin, the AGP with the largest performance increase in our study. Untargeted metabolomics of narasin treated birds aligned with model predictions, suggesting that the core cecum microbiome might be targeted for enhanced performance via its contribution to host-microbiota metabolic crosstalk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.