ArticleCommunications biology2022
A benzodiazepine activator locks K
Abstract read
In one paragraph
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Electro-Mechanical Uncoupling of KArchiv der Pharmazie · 2026Article
- Cannabidiol inhibits both human KActa pharmacologica Sinica · 2026Article
- Discovery of Small-Molecule Inhibitors of the KCNQ1/Kv7.1 Potassium Channel with Virtual Screening and Functional Validation in Electrophysiological Assays and KCNQ1-Knockout Neural Stem Cells.ACS chemical neuroscience · 2026Article
- Structure-Activity Relationship Study on Ligands Activating the Voltage-Gated Potassium Channel KArchiv der Pharmazie · 2026Article
- Structure-Function Relationships of KAdvances in experimental medicine and biology · 2026Review
- Targeting the ICirculation research · 2024Article
- Cloxyquin activates hTRESK by allosteric modulation of the selectivity filter.Communications biology · 2023Article
- Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Hypnotics Use Is Associated with Elevated Incident Atrial Fibrillation: A Propensity-Score Matched Analysis of Cohort Study.Journal of personalized medicine · 2022Article
- Effective Perturbations by Phenobarbital onBiomedicines · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Julian A Schreiber *Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster, D-48149, Münster, Germany.ORCID http://orcid.org/0000-0002-3847-7539
Melina Möller *Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster, D-48149, Münster, Germany.
Mark ZaydmanDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, 63130, USA.
Lu ZhaoDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, 63130, USA.
Zachary BellerDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, 63130, USA.
Sebastian BeckerInstitute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster, D-48149, Münster, Germany.
Nadine RitterInstitute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster, D-48149, Münster, Germany.
Panpan HouDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, 63130, USA.
Jingyi ShiDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, 63130, USA.
Jon SilvaDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, 63130, USA.
Eva WrobelInstitute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster, D-48149, Münster, Germany.
Nathalie Strutz-SeebohmInstitute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster, D-48149, Münster, Germany.
Niels DecherInstitute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, Deutschhausstr. 1-2, 35037, Marburg, Germany.ORCID http://orcid.org/0000-0002-9433-687X
Nicole SchmittDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-9482-9749
Sven G MeuthDepartment of Neurology, University Hospital Düsseldorf, Düsseldorf, Germany.
Martina DüferInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster, Corrensstr. 48, Münster, D-48149, Germany.
Bernhard WünschInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster, Corrensstr. 48, Münster, D-48149, Germany.ORCID http://orcid.org/0000-0002-9030-8417
Jianmin CuiDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, 63130, USA.ORCID http://orcid.org/0000-0002-9198-6332
Guiscard SeebohmInstitute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster, D-48149, Münster, Germany. guiscard.seebohm@ukmuenster.de.ORCID http://orcid.org/0000-0001-9303-5373
Funding
MANIPULATING IKS AS A THERAPEUTIC APPROACH TO CARDIAC ARRHYTHMIASR01HL126774 · NHLBI · WASHINGTON UNIVERSITY · PI CUI, JIANMIN · 2015 to 2018
$3.1MKCNQ CHANNELS: GATING AND SUBUNITS MODULATIONR01NS092570 · NINDS · WASHINGTON UNIVERSITY · PI SILVA, JONATHAN R · 2015 to 2020
$1.7MNHLBI NIH HHS R01 HL126774NINDS NIH HHS R01 NS092570
Abstract
Loss-of-function mutations in K
Indexed as
BenzodiazepinesIon Channel GatingMutationBenzodiazepines
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.