ArticleNature communications2022
ROS homeostasis mediated by MPK4 and SUMM2 determines synergid cell death.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- OsPRK1/2/3-mediated reactive oxygen species signaling is required for pollen tube germination in rice.Journal of integrative plant biology · 2025Article
- lncRNA-Encoded Small Peptide Promotes Viral Infection.Molecular plant pathology · 2025Article
- Fertilization-induced synergid cell death by RALF12-triggered ROS production and ethylene signaling.Nature communications · 2025Article
- Article
- The Role of Female and Male Genes in Regulating Pollen Tube Guidance in Flowering Plants.Genes · 2024Review
- Heat-stress-induced ROS in maize silks cause late pollen tube growth arrest and sterility.iScience · 2024Article
- Soybean MKK2 establishes intricate signalling pathways to regulate soybean response to cyst nematode infection.Molecular plant pathology · 2024Article
- Resistant and SusceptibleInternational journal of molecular sciences · 2023Article
- Uncovering genomic and transcriptional variations facilitates utilization of wild resources in cotton disease resistance improvement.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Fertility loss in senescing Arabidopsis ovules is controlled by the maternal sporophyte via a NAC transcription factor triad.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- During Water Stress, Fertility Modulated by ROS Scavengers Abundant in Arabidopsis Pistils.Plants (Basel, Switzerland) · 2023Article
- Article
- Insulin resistance in ischemic stroke: Mechanisms and therapeutic approaches.Frontiers in endocrinology · 2022Review
- ROS scavenging and ion homeostasis is required for the adaptation of halophyteFrontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sexual plant reproduction depends on the attraction of sperm-cell delivering pollen tubes (PT) by two synergids, followed by their programmed cell death (PCD) in Arabidopsis. Disruption of the mitogen-activated protein kinase 4 (MPK4) by pathogenic effectors activates the resistance protein (R) SUMM2-mediated immunity and cell death. Here we show that synergid preservation and reactive oxygen species (ROS) homeostasis are intimately linked and maintained by MPK4. In mpk4, ROS levels are increased and synergids prematurely undergo PCD before PT-reception. However, ROS scavengers and the disruption of SUMM2, in mpk4, restore ROS homeostasis, synergid maintenance and PT perception, demonstrating that the guardian of MPK4, SUMM2, triggers synergid-PCD. In mpk4/summ2, PTs show a feronia-like overgrowth phenotype. Our results show that immunity-associated PCD and synergid cell death during plant reproduction are regulated by MPK4 underscoring an underlying molecular mechanism for the suppression of plant reproduction during systemic R-mediated immunity.
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