ArticleNature communications2022
Chirality transfer from a 3D macro shape to the molecular level by controlling asymmetric secondary flows.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Giant Circularly Polarized Luminescence Driven by Excited-State Hybridization Between Molecular Emitters and Chiral Environments.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Let's twist again.Nature materials · 2024Article
- Physical Chemistry Models for Chemical Research in the XXth and XXIst Centuries.ACS physical chemistry Au · 2024Review
- Investigation of J-Aggregates of 2,3,7,8,12,13,17,18-Octabromo-5,10,15,20-tetrakis(4-sulfonatophenyl) Porphyrin in Aqueous Solutions.Nanomaterials (Basel, Switzerland) · 2023Article
- Construction of chiral capillary electrochromatography microsystems based on Aspergillus sp. CM96.Mikrochimica acta · 2023Article
- Covalent transfer of chemical gradients onto a graphenic surface with 2D and 3D control.Nature communications · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homochirality is a fundamental feature of living systems, and its origin is still an unsolved mystery. Previous investigations showed that external physical forces can bias a spontaneous symmetry breaking process towards deterministic enantioselection. But can the macroscopic shape of a reactor play a role in chiral symmetry breaking processes? Here we show an example of chirality transfer from the chiral shape of a 3D helical channel to the chirality of supramolecular aggregates, with the handedness of the helical channel dictating the direction of enantioselection in the assembly of an achiral molecule. By combining numerical simulations of fluid flow and mass transport with experimental data, we demonstrated that the chiral information is transferred top-down thanks to the interplay between the hydrodynamics of asymmetric secondary flows and the precise spatiotemporal control of reagent concentration fronts. This result shows the possibility of controlling enantioselectively molecular processes at the nanometer scale by modulating the geometry and the operating conditions of fluidic reactors.
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Registered trials
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