ArticleeNeuro
Alpha EEG Activity and Pupil Diameter Coupling during Inactive Wakefulness in Humans.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- The Pupil-Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics.Psychophysiology · 2026Review
- The anterior cingulate cortex modulates pupil-linked arousal.Science advances · 2026Article
- A Systematic Review of EEG Studies on the Neural Effects of Quran Listening.Iranian journal of psychiatry · 2025Review
- The Interplay of Spontaneous Pupil-Size Fluctuations and EEG Power in Near-Threshold Detection.Psychophysiology · 2025Article
- Prediction of Alpha Power Using Multiple Subjective Measures and Autonomic Responses.Psychophysiology · 2025Article
- Pupil-linked arousal, cortical activity, and cognition in Alzheimer's disease.Brain communications · 2025Article
- Article
- Predicting subjective sleepiness during auditory cognitive testing using voice signaling analysis.Sleep science and practice · 2025Article
- Cross-species real-time detection of trends in pupil size fluctuation.Behavior research methods · 2024Article
- Frontotemporal network contribution to occluded face processing.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Experience Dependence of Alpha Rhythms and Neural Dynamics in the Mouse Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cross-species real time detection of trends in pupil size fluctuation.bioRxiv : the preprint server for biology · 2024Article
- Blink-induced changes in pupil dynamics are consistent and heritable.Research square · 2024Article
- Double Dissociation of Spontaneous Alpha-Band Activity and Pupil-Linked Arousal on Additive and Multiplicative Perceptual Gain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A disinhibitory circuit mechanism explains a general principle of peak performance during mid-level arousal.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Recent trends in multiple metrics and multimodal analysis for neural activity and pupillometry.Frontiers in neurology · 2024Article
- Neural α Oscillations and Pupil Size Differentially Index Cognitive Demand under Competing Audiovisual Task Conditions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Autogenous cerebral processes: an invitation to look at the brain from inside out.Frontiers in neural circuits · 2023Article
- Human-in-the-Loop Optimization of Transcranial Electrical Stimulation at the Point of Care: A Computational Perspective.Brain sciences · 2022Article
- Orexin/Hypocretin System Dysfunction in ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations).Neuropsychiatric disease and treatment · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Variations in human behavior correspond to the adaptation of the nervous system to different internal and environmental demands. Attention, a cognitive process for weighing environmental demands, changes over time. Pupillary activity, which is affected by fluctuating levels of cognitive processing, appears to identify neural dynamics that relate to different states of attention. In mice, for example, pupil dynamics directly correlate with brain state fluctuations. Although, in humans, alpha-band activity is associated with inhibitory processes in cortical networks during visual processing, and its amplitude is modulated by attention, conclusive evidence linking this narrowband activity to pupil changes in time remains sparse. We hypothesize that, as alpha activity and pupil diameter indicate attentional variations over time, these two measures should be comodulated. In this work, we recorded the electroencephalographic (EEG) and pupillary activity of 16 human subjects who had their eyes fixed on a gray screen for 1 min. Our study revealed that the alpha-band amplitude and the high-frequency component of the pupil diameter covariate spontaneously. Specifically, the maximum alpha-band amplitude was observed to occur ∼300 ms before the peak of the pupil diameter. In contrast, the minimum alpha-band amplitude was noted to occur ∼350 ms before the trough of the pupil diameter. The consistent temporal coincidence of these two measurements strongly suggests that the subject's state of attention, as indicated by the EEG alpha amplitude, is changing moment to moment and can be monitored by measuring EEG together with the diameter pupil.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.