ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2022
[Profilin 2 is highly expressed in gastric cancer and promotes tumor cell proliferation and migration].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- The SIX2/PFN2 feedback loop promotes the stemness of gastric cancer cells.Journal of translational medicine · 2024Article
- [High expression of RAB7A is associated with poor prognosis of gastric cancer by promoting tumor invasion].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
objectiveTo investigate the expression of profilin 2 (PFN2) in gastric cancer and assess its potential value as a novel prognostic indicator and a therapeutic target.
methodsWe collected gastric cancer and paired adjacent tissues from 100 patients for immunohistochemical detection of PFN2 expression. According to the expression level of PFN2, the patients were divided into two groups with high (46 cases) and low (48 cases) PNF2 expression in cancer tissues, and also into two groups with high (26 cases) and low (49 cases) PNF2 expression in adjacent tissues. Chi-square test, Spearman correlation and KaplanMeier survival analysis were used to analyze the relationship between PFN2 protein expression level and the patients' clinical parameters. We also tested the effects of PFN2 knockdown and overexpression on the proliferation and migration of MKN-45 cells using Transwell assay and CCK-8 assay.
resultsThe expression of PFN2 protein was significantly higher in gastric cancer tissues than in adjacent tissues (
conclusionPFN2 protein is highly expressed in gastric cancer tissues to promote the proliferation and migration of the tumor cells. PFN2 may serve as a potential diagnostic marker, a prognostic indicator and a therapeutic target for gastric cancer.
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