Evidence map›Paper›PMID 35365180›Full record

ArticleTrials2022

The One Nutrition in Complex Environments (ONCE) study protocol: a cluster-randomized multi-level multi-sectoral intervention to improve nutrition in Uganda.

Stacy P Griswold, Anastasia Marshak, Merry Fitzpatrick, Daniele Lantagne, Kate Shoenmakers, Marlene Hebie, Anne Radday, Hugo De Groote, Saurabh Mehta, Greg Gottlieb and 2 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04209569 (One Nutrition in Complex Environments), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04209569 nacompletednot on this map

One Nutrition in Complex Environments (ONCE), a Cluster-randomized Trial of Nutrition Education and Access to Simple Supportive Technologies in Improving Agricultural Practices and Water Quality Management

TypeinterventionalSponsorTufts UniversityRan2020 to 2022Enrolled1,834ConditionsNutrition Poor, Aflatoxins Toxicity, Water-Related DiseasesArmsNutrition Impact and Positive Practice Circle (NIPP)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Stacy P GriswoldFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA. stacy.griswold@tufts.edu.ORCID http://orcid.org/0000-0001-7572-3316
Anastasia MarshakFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
Merry FitzpatrickFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
Daniele LantagneDepartment of Civil and Environmental Engineering, School of Engineering, Tufts University, Medford, MA, USA.
Kate ShoenmakersGOAL International, Dublin, Ireland.
Marlene HebieGOAL International, Dublin, Ireland.
Anne RaddayFeinstein International Center, Tufts University, Boston, MA, USA.
Hugo De GrooteInternational Maize and Wheat Improvement Centre (CIMMYT), Nairobi, Kenya.
Saurabh MehtaDivision of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
Greg GottliebFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
Patrick WebbFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
Shibani GhoshFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
Tufts University · USGOAL · IECornell University · USInternational Maize and Wheat Improvement Center · KE

Funding

united states agency for international development 7200AA18CA00044
6 · The paper itself

Abstract

objectiveTo implement and measure the effects of a multi-level multi-sectoral social behavior change (SBC) intervention in Agago District of Northern Uganda and to determine the potential for scale-up.

interventionCompare the Nutrition Impact and Positive Practice (NIPP) approach to a NIPP+ approach. The NIPP approach involves nutrition education and SBC, whereas the NIPP+ adds agricultural inputs, training, and tools to support improved farm and water quality practices. The intervention effect will be measured through lower levels of aflatoxin in grain, lower water contamination, and improved knowledge on nutrition and health.

designThis is a three-arm cluster-randomized controlled superiority trial (cRCT). The study arms include the following: group 1: NIPP; group 2: NIPP+, and group 3: control. Groups 1 and 2 will receive a 12-week intervention (NIPP or NIPP+) with active monitoring and longitudinal follow-up at 2, 6, and 12 months post-intervention. Additionally, an in-depth process and performance evaluation of each intervention arm will be undertaken using quantitative and qualitative methods. A total of 60 clusters from 5 subcounties of the Agago district will be randomly selected, and 15 households per cluster will be recruited using specific inclusion/exclusion criteria for a total of 900 households (300/arm). Respondents for the qualitative portion will be purposely selected. ANALYSIS: We will collect data from all participants at 3 time points: baseline, endline, and 12 months post-intervention. The analysis will utilize intent-to-treat (ITT) using the initial randomization of the treatment arms to determine the overall impact of having the NIPP vs. NIPP+ vs. control. Mixed effects models will be used to determine the role of time-variant and invariant individual household, and community characteristics, as well as measures of exposure and integration on key outcome indicators. A difference-in-difference analysis (baseline/endline, baseline/12 months post-intervention, endline/12 months post-intervention) will also be used to triangulate findings.

trial registrationNCT04209569 . One Nutrition in Complex Environments (ONCE) Registered 24 December 2019.

Indexed as

Nutritional StatusNutrition TherapyEquivalence Trials as TopicFamily CharacteristicsHealth EducationHumansRandomized Controlled Trials as TopicUgandaAgricultureCluster-randomized trialNutrition social behavior changeWater

Identifiers

PMID35365180
PMCPMC8972632
OpenAlexW4220685957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.