Evidence map›Paper›PMID 35365121›Full record

ArticleBMC neurology2022

Effects of high frequency rTMS of contralesional dorsal premotor cortex in severe subcortical chronic stroke: protocol of a randomized controlled trial with multimodal neuroimaging assessments.

Jiali Li, Hewei Wang, Yujian Yuan, Yunhui Fan, Fan Liu, Jingjing Zhu, Qing Xu, Lan Chen, Miao Guo, Zhaoying Ji and 6 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Jiali Li *Huashan Hospital, Fudan University, Shanghai, China.
Hewei Wang *Huashan Hospital, Fudan University, Shanghai, China.
Yujian YuanHuashan Hospital, Fudan University, Shanghai, China.
Yunhui FanHuashan Hospital, Fudan University, Shanghai, China.
Fan LiuEast China Normal University, Shanghai, China.
Jingjing ZhuThe Third Rehabilitation Hospital, Shanghai, China.
Qing XuThe Third Rehabilitation Hospital, Shanghai, China.
Lan ChenThe Third Rehabilitation Hospital, Shanghai, China.
Miao GuoEast China Normal University, Shanghai, China.
Zhaoying JiThe Third Rehabilitation Hospital, Shanghai, China.
Yun ChenThe Third Rehabilitation Hospital, Shanghai, China.
Qiurong YuEast China Normal University, Shanghai, China.
Tianhao GaoHuashan Hospital, Fudan University, Shanghai, China.
Yan HuaHuashan Hospital, Fudan University, Shanghai, China.
Mingxia FanEast China Normal University, Shanghai, China.
Limin SunHuashan Hospital, Fudan University, Shanghai, China. tracy611@sina.com.ORCID http://orcid.org/0000-0003-1224-4320
Fudan University · CNShanghai Third People's Hospital · CNEast China Normal University · CN

Funding

National Natural Science Foundation of China 81974356
6 · The paper itself

Abstract

backgroundPrevious studies have revealed that low frequency repeated transcranial magnetic stimulation (rTMS) on the contralesional primary motor cortex (cM1) is less effective in severe stroke patients with poor neural structural reserve than in patients with highly reserved descending motor pathway. This may be attributed to the fact that secondary motor cortex, especially contralesional dorsal premotor cortex (cPMd), might play an important compensatory role in the motor function recovery of severely affected upper extremity. The main purpose of this study is to compare the effectiveness of low frequency rTMS on cM1 and high frequency rTMS on cPMd in subcortical chronic stroke patients with severe hemiplegia. By longitudinal analysis of multimodal neuroimaging data, we hope to elucidate the possible mechanism of brain reorganization following different treatment regimens of rTMS therapy, and to determine the cut-off of stimulation strategy selection based on the degree of neural structural reserve. METHODS/

designThe study will be a single-blinded randomized controlled trial involving a total of 60 subcortical chronic stroke patients with severe upper limb motor impairments. All patients will receive 3 weeks of conventional rehabilitation treatment, while they will be divided into three groups and receive different rTMS treatments: cM1 low frequency rTMS (n = 20), cPMd high frequency rTMS (n = 20), and sham stimulation group (n = 20). Clinical functional assessment, multimodal functional MRI (fMRI) scanning, and electrophysiological measurement will be performed before intervention, 3 weeks after intervention, and 4 weeks after the treatment, respectively. DISCUSSION: This will be the first study to compare the effects of low-frequency rTMS of cM1 and high-frequency rTMS of cPMd. The outcome of this study will provide a theoretical basis for clarifying the bimodal balance-recovery model of stroke, and provide a strategy for individualized rTMS treatment for stroke in future studies and clinical practice.

trial registrationChinese Clinical Trial Registry, ChiCTR1900027399. Registered on 12 Nov 2019, http://www.chictr.org.cn/showproj.aspx?proj=43686 .

Indexed as

Motor CortexStrokeHumansNeuroimagingRandomized Controlled Trials as TopicTranscranial Magnetic StimulationTreatment OutcomeDorsal premotor cortexFunctional MRIHemiplegiaStrokeTranscranial magnetic stimulation

Identifiers

PMID35365121
PMCPMC8973524
OpenAlexW4220902450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.