ArticleBMC ophthalmology2022
Thickness measurements taken with the spectralis OCT increase with decreasing signal strength.
Article in BMC ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- The Rates of Retinal Nerve Fiber Layer Change in Children With Optic Disc Drusen.Ophthalmology science · 2026Article
- Optical coherence tomography acquisition efficiency: comparison of Heidelberg spectralis OCT2 module & Zeiss Cirrus HD-OCT model 6000.Frontiers in ophthalmology · 2026Article
- Comparison of the diagnostic performance of two spectral-domain OCT machines in detecting glaucoma in high and non-high axial myopia eyes.International ophthalmology · 2025Article
- Advancing Non-Invasive Ophthalmic Imaging in Sturge-Weber Syndrome: Clinical Guidelines Towards Early Choroidal Hemangioma Detection.Journal of clinical medicine · 2025Article
- Central retinal volume derived from optical coherence tomography as a potential predictor of mortality in the old-aged population- results from the German AugUR study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Optical Coherence Tomography- and Optical Coherence Tomography Angiography-Based Evaluation in Treatment-Naïve Non-Exudative Macular Neovascularization.Journal of clinical medicine · 2025Article
- Cross-instrument optical coherence tomography-angiography (OCTA)-based prediction of age-related macular degeneration (AMD) disease activity using artificial intelligence.Scientific reports · 2024Article
- Comparison of conventional internal limiting membrane versus pars plana vitrectomy without peeling for small idiopathic macular hole.International journal of retina and vitreous · 2024Article
- Effect of orbital decompression surgery on the choroidal profile in patients with thyroid eye disease.Scientific reports · 2024Article
- Comparison of retinal nerve fiber layer thickness between monocular and alternating exotropia in patients with intermittent exotropia.International ophthalmology · 2024Article
- Cytomegalovirus-positive Posner-Schlossman syndrome: to compare differences in retinal vessel area density between the affected and non-affected eye using optical coherence tomography angiography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Observational
- Quantitative and Qualitative Assessments of Retinal Structure with Variable A-Scan Rate Spectralis OCT: Insights into IPL Multilaminarity.Journal of clinical medicine · 2023Article
- Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOptical coherence tomography (OCT) is used worldwide by clinicians to evaluate macular and retinal nerve fiber layer (RNFL) characteristics. It is frequently utilized to assess disease severity, progression and efficacy of treatment, and therefore must be reliable and reproducible.
objectiveTo examine the influence of signal strength on macular thickness parameters, macular volume measurement and RNFL thickness measured by spectral-domain optical coherence tomography (SD-OCT).
methodsMacular thickness parameters, macular volume measurement and RNFL thickness were measured by the Spectralis® OCT (Heidelberg Engineering, Heidelberg, Germany). In each eye, the focusing knob was adjusted to obtain 4 images with different signal strengths - Low (below 15), Moderate (15-20), Good (20-25) and Excellent (above 25). The relationship between signal strength and measured data was assessed using the mixed model procedure.
resultsA total of 71 eyes of 41 healthy subjects were included. Central macular thickness, macular volume and mean RNFL thickness increased with decreasing signal strength. Specifically, eyes with excellent signal strength showed significantly thinner central macular thickness (p = 0.023), macular volume (p = 0.047), and mean RNFL thickness (p = 0.0139).
conclusionsHigher signal strength is associated with lower macular thickness, macular volume and RNFL thickness measurements. The mean differences between excellent and low-quality measurements were small implicating that SD-OCT is a reliable imaging tool even at low quality scans. It is imperative that the physician compares the signal strength of all scans, as minute differences may alter results.
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