Evidence map›Paper›PMID 35364811›Full record

ArticleJournal of the American Chemical Society2022

Donor-Acceptor Pyridinium Salts for Photo-Induced Electron-Transfer-Driven Modification of Tryptophan in Peptides, Proteins, and Proteomes Using Visible Light.

Caleb R Hoopes, Francisco J Garcia, Akash M Sarkar, Nicholas J Kuehl, David T Barkan, Nicole L Collins, Glenna E Meister, Taylor R Bramhall, Chien-Hsiang Hsu, Michael D Jones and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 62 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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  7. Site-Selective Peptide and Protein Functionalization with Cyclopropenium Cations.Angewandte Chemie (International ed. in English) · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Light-Activated Reactivity of Nitrones with Amino Acids and Proteins.Angewandte Chemie (International ed. in English) · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Caleb R HoopesDepartment of Chemistry, University of Wyoming, Laramie, Wyoming 82071, United States.
Francisco J GarciaNovartis Institutes for Biomedical Research, 181 Massachusetts Ave, Cambridge, Massachusetts 02139, United States.
Akash M SarkarDepartment of Chemistry, University of Wyoming, Laramie, Wyoming 82071, United States.ORCID 0000-0002-0277-6916
Nicholas J KuehlDepartment of Chemistry, University of Wyoming, Laramie, Wyoming 82071, United States.
David T BarkanNovartis Institutes for Biomedical Research, 181 Massachusetts Ave, Cambridge, Massachusetts 02139, United States.
Nicole L CollinsDepartment of Chemistry, University of Wyoming, Laramie, Wyoming 82071, United States.
Glenna E MeisterNovartis Institutes for Biomedical Research, 181 Massachusetts Ave, Cambridge, Massachusetts 02139, United States.
Taylor R BramhallNovartis Institutes for Biomedical Research, 181 Massachusetts Ave, Cambridge, Massachusetts 02139, United States.
Chien-Hsiang HsuNovartis Institutes for Biomedical Research, 181 Massachusetts Ave, Cambridge, Massachusetts 02139, United States.
Michael D JonesNovartis Institutes for Biomedical Research, 181 Massachusetts Ave, Cambridge, Massachusetts 02139, United States.
Markus SchirleNovartis Institutes for Biomedical Research, 181 Massachusetts Ave, Cambridge, Massachusetts 02139, United States.ORCID 0000-0003-4933-2623
Michael T TaylorDepartment of Chemistry, University of Wyoming, Laramie, Wyoming 82071, United States.ORCID 0000-0002-7655-7222
University of Wyoming · US

Funding

Zebrafish Models of CNS Injury and Locomotor RecoveryP20GM121310 · NIGMS · UNIVERSITY OF WYOMING · PI Qian-Quan Sun · 2017 to 2026
$27.2M
NIGMS NIH HHS P20 GM121310
6 · The paper itself

Abstract

Tryptophan (Trp) plays a variety of critical functional roles in protein biochemistry; however, owing to its low natural frequency and poor nucleophilicity, the design of effective methods for both single protein bioconjugation at Trp as well as for

Indexed as

ProteomeTryptophanElectronsHEK293 CellsHumansLightPeptidesSaltsPeptidesProteomeSaltsTryptophan

Identifiers

PMID35364811
PMCPMC10124759
OpenAlexW4225523467

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.