Evidence map›Paper›PMID 35364728›Full record

ArticleArchives of osteoporosis2022

Incidence of different types of subsequent fractures and related mortality in Taiwan.

Jiun-Liang Chen, Ta-Wei Tai, Che-Yi Chou, Chieh-Ko Ku, Li-Nien Chien, Tsan-Wen Huang, Chao-Hsuin Tang

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Article in Archives of osteoporosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Incidence, risk factors, prognosis of periprosthetic fractures post hip fracture: unveiling protective role of anti-osteoporotic medication.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
  5. Article
  6. Article
  7. Opportunistically identifiable vertebral fractures on routine radiological imaging predict mortality: observational cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Observational
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiun-Liang ChenDepartment of Orthopedic Surgery, Chiayi Chang Gung Memorial Hospital, Puzi, Chiayi, Taiwan.
Ta-Wei TaiDepartment of Orphopedics, National Cheng Kung University Hospital, Tainan, Taiwan.
Che-Yi ChouDivision of Nephrology, Asia University Hospital, Wufeng, Taichung, Taiwan.
Chieh-Ko KuMedical Affairs, Amgen Taiwan, Taipei, Taiwan.
Li-Nien ChienSchool of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan.
Tsan-Wen HuangDepartment of Orthopedic Surgery, Chiayi Chang Gung Memorial Hospital, Puzi, Chiayi, Taiwan. b8601081@cgmh.org.tw.
Chao-Hsuin TangSchool of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan. chtang@tmu.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hip fracture is the most common type of fracture to occur within 2 years after an initial fracture. Mortality risk increases when a subsequent fracture occurs. The occurrence of subsequent fracture is significantly higher in patients with hip fractures than others. Prevention of subsequent fracture is of paramount important. PURPOSE: Osteoporotic fracture significantly increases risk of subsequent fracture. In this retrospective cohort study, we used the Taiwan National Health Insurance Database (NHIRD) to analyze data on fractures in a group at high risk of osteoporosis. We aimed to distinguish differences in subsequent fracture types and their relationship with mortality.

methodsWe enrolled patients aged ≥ 50 years old who were diagnosed with an initial fracture classified as hip, vertebral, upper end of the humerus, or wrist. Data from 2 years of follow-up were analyzed. Risks of subsequent fracture events and mortality were calculated by Kaplan-Meier estimation and assessed with Cox proportional hazards models.

resultsWe included 375,836 patients from the 2011-2015 NHIRD. Patients with initial hip fracture had the highest incidence of subsequent fracture at both 1- and 2-year follow-up (7.0% and 10.9%). Subsequent fractures occurred mainly at the hip. Conversely, other patients had a higher proportion of subsequent vertebral fracture. Patients with subsequent fracture classified as hip, vertebral, and upper end of the humerus had significantly higher cumulative mortality rates than that of patients who had no subsequent fracture, with adjusted hazard ratios of 1.64 (95% CI = 1.57-1.71, p < 0.01), 1.06 (95% CI = 1.00-1.12, p = 0.04), 1.31 (95% CI = 1.17-1.46, p < 0.01), respectively.

conclusionPatients who experienced an initial hip fracture are at greatest risk of subsequent fracture, most commonly the hip. Occurrence of subsequent fractures was associated with an increased mortality risk. Thus, there is a need for early intervention following initial hip fractures.

Indexed as

Osteoporotic FracturesSpinal FracturesHumansIncidenceMiddle AgedRetrospective StudiesTaiwanImminent risk of fractureIncidenceMortalityNational databaseOsteoporotic fractureSubsequent fracture

Identifiers

PMID35364728

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.