ReviewVirchows Archiv : an international journal of pathology2022
Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?
Review in Virchows Archiv : an international journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- A survey of SARS-CoV-2 tropism.Infectious diseases & immunity · 2025Review
- Evaluation of circulating microvesicles and their procoagulant activity in patients with COVID-19.BMC research notes · 2024Article
- Article
- Proteomic lung analysis revealed hyper-activation of neutrophil extracellular trap formation in cases of fatal COVID-19.Heliyon · 2024Article
- Cardioprotective effects of vaccination in hospitalized patients with COVID-19.Clinical and experimental medicine · 2024Article
- Impact of Symptomatology, Clinical and Radiological Severity of COVID-19 on Pulmonary Function Test Results and Functional Capacity during Follow-Up among Survivors.Journal of clinical medicine · 2023Article
- Liver function tests at admission as marker of severity and prognosis in COVID-19 patients - A retrospective analysis.Journal of family medicine and primary care · 2023Article
- [Interdisciplinary ultrasound-guided, minimally invasive autopsy in COVID-19-deceased patients in the intensive care unit of a university hospital : A proof-of-concept study].Pathologie (Heidelberg, Germany) · 2023Review
- Using autopsies to dissect COVID-19 pathogenesis.Nature microbiology · 2023Review
- Minimally invasive autopsies for the investigation of pulmonary pathology of COVID-19-experiences of a longitudinal series of 92 patients.Virchows Archiv : an international journal of pathology · 2023Article
- Pathomorphological Features of the Novel Coronavirus Disease in Patients with Systemic Amyloidosis.Biomedicines · 2023Article
- Article
- Heparin, Low Molecular Weight Heparin, and Non-Anticoagulant Derivatives for the Treatment of Inflammatory Lung Disease.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Neuropathological features of SARS-CoV-2 delta and omicron variants.Journal of neuropathology and experimental neurology · 2023Article
- What do we know about pathological mechanism and pattern of lung injury related to SARS-CoV-2 Omicron variant?Diagnostic pathology · 2023Article
- Close collaboration between pathologists and intensivists to understand (not just) coronavirus disease.Intensive care medicine · 2023Article
- SARS-CoV-2 cellular tropism and direct multiorgan failure in COVID-19 patients: Bioinformatic predictions, experimental observations, and open questions.Cell biology international · 2023Review
- Microvascular Thrombosis as a Critical Factor in Severe COVID-19.International journal of molecular sciences · 2023Article
- Post-mortem findings in Spanish patients with COVID-19; a special focus on superinfections.Frontiers in medicine · 2023Article
- [Clinical features of children with coronavirus disease 2019 complicated by acute encephalitis and related research advances].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Review
Corrections and comments
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Authors and funding
57 authors at 20 institutions in 1 country.
Funding
Abstract
The use of autopsies in medicine has been declining. The COVID-19 pandemic has documented and rejuvenated the importance of autopsies as a tool of modern medicine. In this review, we discuss the various autopsy techniques, the applicability of modern analytical methods to understand the pathophysiology of COVID-19, the major pathological organ findings, limitations or current studies, and open questions. This article summarizes published literature and the consented experience of the nationwide network of clinical, neuro-, and forensic pathologists from 27 German autopsy centers with more than 1200 COVID-19 autopsies. The autopsy tissues revealed that SARS-CoV-2 can be found in virtually all human organs and tissues, and the majority of cells. Autopsies have revealed the organ and tissue tropism of SARS-CoV-2, and the morphological features of COVID-19. This is characterized by diffuse alveolar damage, combined with angiocentric disease, which in turn is characterized by endothelial dysfunction, vascular inflammation, (micro-) thrombosis, vasoconstriction, and intussusceptive angiogenesis. These findings explained the increased pulmonary resistance in COVID-19 and supported the recommendations for antithrombotic treatment in COVID-19. In contrast, in extra-respiratory organs, pathological changes are often nonspecific and unclear to which extent these changes are due to direct infection vs. indirect/secondary mechanisms of organ injury, or a combination thereof. Ongoing research using autopsies aims at answering questions on disease mechanisms, e.g., focusing on variants of concern, and future challenges, such as post-COVID conditions. Autopsies are an invaluable tool in medicine and national and international interdisciplinary collaborative autopsy-based research initiatives are essential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.