ArticleThe Journal of pediatrics2022
The Epidemiology of Biliary Atresia: Exploring the Role of Developmental Factors on Birth Prevalence.
Article in The Journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Population-based screening strategies for biliary atresia in the newborn: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Diagnostic and management guidelines for biliary atresia in 2025.Hepatobiliary surgery and nutrition · 2026Review
- Effects of post-hepatic portoenterostomy adjuvant therapy on liver transplantation in children with biliary atresia: A systematic review.JPGN reports · 2026Article
- A nomogram for predicting early- and mid-term native liver survival after surgery in patients with type III biliary atresia: a single-center retrospective study.BMC surgery · 2026Article
- Association of postoperative infection with early bilirubin clearance and native liver survival: a single - center retrospective cohort study.BMC pediatrics · 2026Article
- Long-term outcomes of liver transplantation in biliary atresia: a 20-year single-center study.Pediatric surgery international · 2026Article
- Early Prediction of Biliary Atresia Using Combi-Elastography in Infants ≤ 60 Days of Age.Diagnostics (Basel, Switzerland) · 2026Article
- Lack of association between cytomegalovirus infection and liver fibrosis in patients with biliary atresia after the Kasai procedure.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Biliary atresia-related liver fibrosis.Frontiers in cell and developmental biology · 2026Review
- Maternal risk factors for biliary atresia in neonates: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Review
- Endoscopic retrograde cholangiopancreatography as a diagnostic key tool for biliary atresia: feasibility, safety and accuracy in neonates with cholestatic liver disease.European journal of pediatrics · 2025Article
- Experience of post-traumatic growth among parents of children with biliary atresia undergoing living-related liver transplantation: a descriptive phenomenological study.European journal of psychotraumatology · 2025Article
- Cross-country multi-modal evidence links Aspergillus to biliary atresia.Gut pathogens · 2025Article
- Inflammatory factor CCL2 enhances the interaction between monocyte-macrophage cells and liver parenchymal cells to promote liver inflammation and fibrosis in biliary atresia.BMC pediatrics · 2025Article
- Varied Characteristics of Recovered Patients with Biliary Atresia.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025Observational
- Prenatal Exposure to Air Pollution and Pediatric Biliary Atresia: A Nationwide Population-Based Cohort Study.Digestive diseases and sciences · 2025Article
- Serum FGF19 combined with GGT and other biomarkers predicted native liver survival following Kasai portoenterostomy in early biliary atresia.Journal of gastroenterology · 2025Article
- Incidence of biliary atresia in the United States before and during the COVID-19 pandemic.Journal of pediatric gastroenterology and nutrition · 2025Article
- Development of an artificial intelligence-based multimodal diagnostic system for early detection of biliary atresia.BMC medicine · 2025Article
- Syndromic variants of biliary atresia.World journal of pediatric surgery · 2025Review
Corrections and comments
- Commented on by
Authors and funding
14 authors at 8 institutions in 1 country.
Funding
Abstract
objectiveTo identify key epidemiologic factors relevant to fetal development that are associated with biliary atresia. STUDY
designThis population-based registry study examined infants born in Texas between 1999 and 2014. Epidemiologic data relevant to fetal development were compared between cases of biliary atresia identified in the Texas Birth Defects Registry (n = 305) vs all live births (n = 4 689 920), and Poisson regression was used to calculate prevalence ratios (PRs) and 95% CIs.
resultsThe prevalence of biliary atresia over the study period was 0.65 per 10 000 live births. Biliary atresia was positively associated with female sex (adjusted PR, 1.68; 95% CI, 1.33-2.12), delivery before 32-37 weeks of gestation (adjusted PR, 1.64; 95% CI, 1.18-2.29), delivery before 32 weeks of gestation (adjusted PR, 3.85; 95% CI, 2.38-6.22), and non-Hispanic Black vs non-Hispanic White maternal race/ethnicity (adjusted PR, 1.54, 95% CI, 1.06-2.24), while biliary atresia was inversely associated with season of conception in the fall relative to spring (adjusted PR, 0.62; 95% CI, 0.45-0.86). In addition, biliary atresia was associated with maternal diabetes (adjusted PR, 2.34; 95% CI, 1.57-3.48), with a stronger association with pregestational diabetes compared with gestational diabetes. In subgroup analyses, these associations were present in isolated biliary atresia cases that do not have any additional birth defects.
conclusionsBiliary atresia is associated with multiple factors related to fetal development, including pregestational maternal diabetes, female sex, and preterm birth. These associations also were observed in isolated cases of biliary atresia without other malformations or laterality defects. Our results are consistent with early life events influencing the pathogenesis of biliary atresia, and support further studies investigating in utero events to better understand etiology and time of onset.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.