Evidence map›Paper›PMID 35364008›Full record

ArticleStem cell reports2022

WNT16B enhances the proliferation and self-renewal of limbal epithelial cells via CXCR4/MEK/ERK signaling.

Songjiao Zhao, Xichen Wan, Yiqin Dai, Lan Gong, Qihua Le

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

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  13. Soluble CD83 Accelerates Wound Healing and Attenuates Inflammatory Responses Induced by Chronic Wound Fluid in a Human 3D in Vitro Wound Healing Model.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Songjiao ZhaoDepartment of Ophthalmology, Eye, Ear, Nose & Throat Hospital of Fudan University, No. 83 Fenyang Road, Shanghai 200031, China.
Xichen WanDepartment of Ophthalmology, Eye, Ear, Nose & Throat Hospital of Fudan University, No. 83 Fenyang Road, Shanghai 200031, China.
Yiqin DaiDepartment of Ophthalmology, Eye, Ear, Nose & Throat Hospital of Fudan University, No. 83 Fenyang Road, Shanghai 200031, China; Research Center, Eye, Ear, Nose & Throat Hospital of Fudan University, Shanghai 200031, China; Myopia Key Laboratory of Ministry of Health, Eye, Ear, Nose & Throat Hospital of Fudan University, Shanghai 200031, China.
Lan GongDepartment of Ophthalmology, Eye, Ear, Nose & Throat Hospital of Fudan University, No. 83 Fenyang Road, Shanghai 200031, China; Myopia Key Laboratory of Ministry of Health, Eye, Ear, Nose & Throat Hospital of Fudan University, Shanghai 200031, China. Electronic address: 13501798683@139.com.
Qihua LeDepartment of Ophthalmology, Eye, Ear, Nose & Throat Hospital of Fudan University, No. 83 Fenyang Road, Shanghai 200031, China; Research Center, Eye, Ear, Nose & Throat Hospital of Fudan University, Shanghai 200031, China; Myopia Key Laboratory of Ministry of Health, Eye, Ear, Nose & Throat Hospital of Fudan University, Shanghai 200031, China. Electronic address: qihuale_eent@163.com.
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Culture of limbal epithelial cells (LECs) provides the principal source of transplanted limbal stem cells (LESCs) for treatment of limbal-stem-cell deficiency. Optimization of the culture conditions for in-vitro-expanded LECs will help to create a graft with an optimized quality and quantity of LESCs. This study aimed to investigate the effects of WNT16B on LECs and corneal wound healing and the underlying mechanism. Treatment with exogenous WNT16B increased the proliferative capacity and self-renewal of LECs in the cultures. We further revealed that C-X-C chemokine receptor type 4 (CXCR4) was vital for the effects of WNT16B, and activation of CXCR4/MEK/ERK signaling was pivotal in mediating the effects of WNT16B on LECs enriched for LESCs. The stimulatory effect of WNT16B on corneal epithelial repair was confirmed in a mouse corneal-wound-healing model. In summary, WNT16B enhances proliferation and self-renewal of LECs via the CXCR4/MEK/ERK signaling cascade and accelerates corneal-epithelial wound healing.

Indexed as

Epithelium, CornealLimbus CorneaeReceptors, CXCR4Wnt ProteinsAnimalsCell ProliferationCells, CulturedEpithelial CellsMiceMitogen-Activated Protein Kinase KinasesWound HealingCXCR4 protein, mouseMitogen-Activated Protein Kinase KinasesReceptors, CXCR4Wnt ProteinsCXCR4limbal epithelial stem cellproliferationself-renewalWNT16B

Identifiers

PMID35364008
PMCPMC9023808
OpenAlexW4221136947

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.