ArticleThe Journal of clinical endocrinology and metabolism2022
Kidney Stone Events Following Parathyroidectomy vs Nonoperative Management for Primary Hyperparathyroidism.
Article in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Effect of parathyroidectomy on stone recurrence in primary hyperparathyroidism : A systematic review.Wiener klinische Wochenschrift · 2026Pooled it
- Systematic review of the risk of urolithiasis following parathyroidectomy in patients with primary hyperparathyroidism.International urology and nephrology · 2024Pooled it
- Evaluating the incidence of nephrolithiasis surgery before and after parathyroidectomy.International urology and nephrology · 2026Article
- Evaluation of breast calcif ication, calcif ication characteristics, and BI-RADS categories in patients with primary hyperparathyroidism.Archives of endocrinology and metabolism · 2026Article
- Article
- Healthcare utilization by patients with primary hyperparathyroidism What is the effect of kidney stone formation?Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2025Article
- The Landmark Series: Management of Primary Hyperparathyroidism.Annals of surgical oncology · 2025Review
- Results of a novel intervention to increase rates of diagnosis and treatment of primary hyperparathyroidism.American journal of surgery · 2024Article
- Unveiling the hidden culprit: Parathyroid adenoma induced recurrent renal calculus and pancreatitis-A case report.Clinical case reports · 2024Article
- Natural history and complications of normocalcemic hyperparathyroidism: a retrospective cohort study.JBMR plus · 2024Article
- Sex-Stratified Predictors of Prolonged Operative Time and Hospital Admission in Outpatient Parathyroidectomy.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Disparities in access to high-volume parathyroid surgeons in the United States: A call to action.Surgery · 2024Article
- Potential for Urolithiasis-related Research Using the Novel Medicare-Litholink Database.Urology practice · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
contextPrimary hyperparathyroidism (PHPT) is associated with an increased risk of kidney stones. Few studies account for PHPT severity or stone risk when comparing stone events after parathyroidectomy vs nonoperative management.
objectiveCompare the incidence of kidney stone events in PHPT patients treated with parathyroidectomy vs nonoperative management.
designLongitudinal cohort study with propensity score inverse probability weighting and multivariable Cox proportional hazards regression.
settingVeterans Health Administration integrated health care system. PATIENTS: A total of 44 978 patients with > 2 years follow-up after PHPT diagnosis (2000-2018); 5244 patients (11.7%) were treated with parathyroidectomy. MAIN OUTCOMES MEASURE: Clinically significant kidney stone event.
resultsThe cohort had a mean age of 66.0 years, was 87.8% male, and 66.4% White. Patients treated with parathyroidectomy had higher mean serum calcium (11.2 vs 10.8mg/dL) and were more likely to have a history of kidney stone events. Among patients with baseline history of kidney stones, the unadjusted incidence of ≥ 1 kidney stone event was 30.5% in patients managed with parathyroidectomy (mean follow-up, 5.6 years) compared with 18.0% in those managed nonoperatively (mean follow-up, 5.0 years). Patients treated with parathyroidectomy had a higher adjusted hazard of recurrent kidney stone events (hazard ratio [HR], 1.98; 95% CI, 1.56-2.51); however, this association declined over time (parathyroidectomy × time: HR, 0.80; 95% CI, 0.73-0.87).
conclusionIn this predominantly male cohort with PHPT, patients treated with parathyroidectomy continued to be at higher risk of kidney stone events in the immediate years after treatment than patients managed nonoperatively, although the adjusted risk of stone events declined with time, suggesting a benefit to surgical treatment.
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