Evidence map›Paper›PMID 35363477›Full record

ArticleACS synthetic biology2022

Parameterized Computational Framework for the Description and Design of Genetic Circuits of Morphogenesis Based on Contact-Dependent Signaling and Changes in Cell-Cell Adhesion.

Calvin Lam, Sajeev Saluja, George Courcoubetis, Dottie Yu, Christian Chung, Josquin Courte, Leonardo Morsut

Open access · greenAbstract read
In one paragraph

Article in ACS synthetic biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Cell Surface Engineering Tools for Programming Living Assemblies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Calvin LamEli and Edythe Broad CIRM Center, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033-9080, United States.
Sajeev SalujaEli and Edythe Broad CIRM Center, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033-9080, United States.ORCID 0000-0002-5191-1897
George CourcoubetisDepartment of Physics and Astronomy, University of Southern California, Los Angeles, California 90089-0484, United States.
Dottie YuEli and Edythe Broad CIRM Center, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033-9080, United States.
Christian ChungEli and Edythe Broad CIRM Center, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033-9080, United States.ORCID 0000-0001-9281-4439
Josquin CourteEli and Edythe Broad CIRM Center, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033-9080, United States.
Leonardo MorsutEli and Edythe Broad CIRM Center, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033-9080, United States.ORCID 0000-0001-7049-3478
University of Southern California · US

Funding

Synthetic development: dissection of morphogenetic programs via reconstructive and perturbative approachesR35GM138256 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MORSUT, LEONARDO · 2020 to 2024
$2.1M
Engineering Synthetic Receptor Systems That Can Detect Specific Cell-Cell Contact R00EB021030 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MORSUT, LEONARDO · 2017 to 2019
$716k
NIBIB NIH HHS R00 EB021030NIGMS NIH HHS R35 GM138256
6 · The paper itself

Abstract

Synthetic development is a nascent field of research that uses the tools of synthetic biology to design genetic programs directing cellular patterning and morphogenesis in higher eukaryotic cells, such as mammalian cells. One specific example of such synthetic genetic programs was based on cell-cell contact-dependent signaling using synthetic Notch pathways and was shown to drive the formation of multilayered spheroids by modulating cell-cell adhesion

Indexed as

Gene Regulatory NetworksSynthetic BiologyAnimalsCell AdhesionMammalsMiceMorphogenesisSignal Transductioncellular Pottscomputational modelingjuxtacrine signalingmorphogenesispatterningself-organizationsynNotchsynthetic biologytissue engineering

Identifiers

PMID35363477
PMCPMC10389258
OpenAlexW4224020843

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.