Evidence map›Paper›PMID 35363468›Full record

ArticleJournal of the American Chemical Society2022

μMap-Red: Proximity Labeling by Red Light Photocatalysis.

Benito F Buksh, Steve D Knutson, James V Oakley, Noah B Bissonnette, Daniel G Oblinsky, Michael P Schwoerer, Ciaran P Seath, Jacob B Geri, Frances P Rodriguez-Rivera, Dann L Parker and 3 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
13.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 1 synthesis or guideline pooled it, 133 citations in OpenAlex.

  1. Pooled it
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Benito F BukshMerck Center for Catalysis at Princeton University, Princeton, New Jersey08544, United States.
Steve D KnutsonMerck Center for Catalysis at Princeton University, Princeton, New Jersey08544, United States.
James V OakleyMerck Center for Catalysis at Princeton University, Princeton, New Jersey08544, United States.
Noah B BissonnetteMerck Center for Catalysis at Princeton University, Princeton, New Jersey08544, United States.ORCID 0000-0001-6892-5040
Daniel G OblinskyDepartment of Chemistry, Princeton University, Princeton, New Jersey08544, United States.ORCID 0000-0001-7460-8260
Michael P SchwoererDepartment of Molecular Biology, Princeton University, Princeton, New Jersey08544, United States.
Ciaran P SeathMerck Center for Catalysis at Princeton University, Princeton, New Jersey08544, United States.
Jacob B GeriMerck Center for Catalysis at Princeton University, Princeton, New Jersey08544, United States.
Frances P Rodriguez-RiveraDiscovery Chemistry, Merck & Co., Kenilworth, New Jersey07033, United States.ORCID 0000-0003-0651-8639
Dann L ParkerDiscovery Chemistry, Merck & Co., Kenilworth, New Jersey07033, United States.
Gregory D ScholesDepartment of Chemistry, Princeton University, Princeton, New Jersey08544, United States.ORCID 0000-0003-3336-7960
Alexander PlossDepartment of Molecular Biology, Princeton University, Princeton, New Jersey08544, United States.ORCID 0000-0001-9322-7252
David W C MacMillanMerck Center for Catalysis at Princeton University, Princeton, New Jersey08544, United States.ORCID 0000-0001-6447-0587
Princeton University · USMerck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI STEVEN ZHENG · 1997 to 2026
$94.5M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4M
Photoredox Catalysis Applications in Organometallics and Chemical BiologyR35GM134897 · NIGMS · PRINCETON UNIVERSITY · PI David W MacMillan · 2020 to 2026
$6.3M
High-Resolution Mapping of Subcellular RNA Dynamics Using Photocatalytic Proximity LabelingF32GM142206 · NIGMS · PRINCETON UNIVERSITY · PI KNUTSON, STEVEN DOUGLAS · 2021 to 2023
$202k
NCI NIH HHS P30 CA072720NIGMS NIH HHS F32 GM142206NIGMS NIH HHS R35 GM134897NIGMS NIH HHS T32 GM007388
6 · The paper itself

Abstract

Modern proximity labeling techniques have enabled significant advances in understanding biomolecular interactions. However, current tools primarily utilize activation modes that are incompatible with complex biological environments, limiting our ability to interrogate cell- and tissue-level microenvironments in animal models. Here, we report μMap-Red, a proximity labeling platform that uses a red-light-excited Sn

Indexed as

BiotinProteomicsAnimalsLightMembrane ProteinsMiceStaining and LabelingBiotinMembrane Proteins

Identifiers

PMID35363468
PMCPMC9843638
OpenAlexW4220987448

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.