Evidence map›Paper›PMID 35363391›Full record

ArticleMedical physics2022

Technical assessment of 2D and 3D imaging performance of an IGZO-based flat-panel X-ray detector.

Niral M Sheth, Ali Uneri, Patrick A Helm, Wojciech Zbijewski, Jeffrey H Siewerdsen

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In one paragraph

Article in Medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Niral M ShethDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Ali UneriDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Patrick A HelmMedtronic, Inc, Littleton, Massachusetts, USA.
Wojciech ZbijewskiDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Jeffrey H SiewerdsenDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.

Funding

Imaging, Guidance, and QA for Emerging High-Precision Neurosurgical TechniquesU01NS107133 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SIEWERDSEN, JEFFREY H, UNERI, ALI · 2019 to 2023
$3.3M
Academic-industry collaboration with Medtronic (Littleton, MA)NIH U01 NS-107133NINDS NIH HHS U01 NS107133
6 · The paper itself

Abstract

backgroundIndirect detection flat-panel detectors (FPDs) consisting of hydrogenated amorphous silicon (a-Si:H) thin-film transistors (TFTs) are a prevalent technology for digital x-ray imaging. However, their performance is challenged in applications requiring low exposure levels, high spatial resolution, and high frame rate. Emerging FPD designs using metal oxide TFTs may offer potential performance improvements compared to FPDs based on a-Si:H TFTs. PURPOSE: This work investigates the imaging performance of a new indium gallium zinc oxide (IGZO) TFT-based detector in 2D fluoroscopy and 3D cone-beam CT (CBCT).

methodsThe new FPD consists of a sensor array combining IGZO TFTs with a-Si:H photodiodes and a 0.7-mm thick CsI:Tl scintillator. The FPD was implemented on an x-ray imaging bench with system geometry emulating intraoperative CBCT. A conventional FPD with a-Si:H TFTs and a 0.6-mm thick CsI:Tl scintillator was similarly implemented as a basis of comparison. 2D imaging performance was characterized in terms of electronic noise, sensitivity, linearity, lag, spatial resolution (modulation transfer function, MTF), image noise (noise-power spectrum, NPS), and detective quantum efficiency (DQE) with entrance air kerma (EAK) ranging from 0.3 to 1.2 μGy. 3D imaging performance was evaluated in terms of the 3D MTF and noise-equivalent quanta (NEQ), soft-tissue contrast-to-noise ratio (CNR), and image quality evident in anthropomorphic phantoms for a range of anatomical sites and dose, with weighted air kerma,

resultsThe 2D imaging performance of the IGZO-based FPD exhibited up to ∼1.7× lower electronic noise than the a-Si:H FPD at matched pixel pitch. Furthermore, the IGZO FPD exhibited ∼27% increase in mid-frequency DQE (1 mm

conclusionThe IGZO-based FPD demonstrated improvements in electronic noise, image lag, and NEQ that translated to measurable improvements in 2D and 3D imaging performance compared to a conventional FPD based on a-Si:H TFTs. The improvements are most beneficial for 2D or 3D imaging scenarios involving low-dose and/or high-frame rate.

Indexed as

GalliumZinc OxideImaging, Three-DimensionalIndiumPhantoms, ImagingX-RaysZincGalliumIndiumZincZinc Oxideamorphous siliconcone-beam CTDQEflat-panel detectorfluoroscopyIGZOimage-guided proceduresMTFNEQNPStechnical assessment

Identifiers

PMID35363391
PMCPMC10153656

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.