Evidence map›Paper›PMID 35363116›Full record

ArticleAutophagy2023

Upstream open reading frames mediate autophagy-related protein translation.

Ying Yang, Damián Gatica, Xu Liu, Runliu Wu, Rui Kang, Daolin Tang, Daniel J Klionsky

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Enhancement of Therapeutic mRNA Translation in Cellular Stress Conditions.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Article
  4. bioRxiv : the preprint server for biology · 2024
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ying YangDepartment of Molecular, Cellular and Developmental Biology, and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-1602-1212
Damián GaticaDepartment of Molecular, Cellular and Developmental Biology, and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Xu LiuDepartment of Molecular, Cellular and Developmental Biology, and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Runliu WuDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Rui KangDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-2725-1574
Daolin TangDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-1903-6180
Daniel J KlionskyDepartment of Molecular, Cellular and Developmental Biology, and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-7828-8118
University of Michigan · USSouthwestern Medical Center

Funding

The mechanism and regulation of autophagyR35GM131919 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DANIEL J. KLIONSKY · 2019 to 2026
$6.4M
Targeting HMGB1-mediated Autophagy in Cancer TherapyR01CA160417 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI TANG, DAOLIN · 2012 to 2023
$3.0M
The Pancreatic Cancer MicroenvironmentR01CA211070 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI KANG, RUI · 2017 to 2023
$1.4M
NCI NIH HHS R01 CA160417NCI NIH HHS R01 CA211070NIGMS NIH HHS R35 GM131919
6 · The paper itself

Abstract

Macroautophagy/autophagy, a highly conserved catabolic pathway that maintains proper cellular homeostasis is stringently regulated by numerous autophagy-related (Atg) proteins. Many studies have investigated autophagy regulation at the transcriptional level; however, relatively little is known about translational control. Here, we report the upstream open reading frame (uORF)-mediated translational control of multiple Atg proteins in

Indexed as

Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAdaptor Proteins, Signal TransducingAutophagyAutophagy-Related ProteinsHumansOpen Reading FramesProtein BiosynthesisTranscription FactorsAdaptor Proteins, Signal TransducingATG13 protein, S cerevisiaeAutophagy-Related ProteinsSaccharomyces cerevisiae ProteinsTranscription FactorsAutophagyhumanlysosomestresstranslational regulationvacuoleyeast

Identifiers

PMID35363116
PMCPMC9851245
OpenAlexW4221040498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.